Sleep-disordered breathing and chronic atrial fibrillation

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dc.contributor.authorSilva, Betania Braga [UNIFESP]
dc.contributor.authorPoyares, Dalva [UNIFESP]
dc.contributor.authorCintra, Fátima Dumas [UNIFESP]
dc.contributor.authorGuilleminault, Christian
dc.contributor.authorCirenza, Claudio [UNIFESP]
dc.contributor.authorHorbach, Stevie Jorge [UNIFESP]
dc.contributor.authorMacedo, D. [UNIFESP]
dc.contributor.authorSantos-Silva, Rogerio [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorDe Paola, Angelo Amato Vincenzo [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionStanford Univ
dc.date.accessioned2016-01-24T13:52:15Z
dc.date.available2016-01-24T13:52:15Z
dc.date.issued2009-02-01
dc.description.abstractBackground: Little has been known about the prevalence of sleep apnea in patients with atrial fibrillation (AF). Studies have suggested that the prevalence of AF is increasing in patients with sleep-disordered breathing. We hypothesize that the prevalence of OSA is higher in chronic persistent and permanent AF patients than a sub-sample of the general population without this arrhythmic disorder.Objective: Evaluate the frequency of Obstructive Sleep Apnea in a sample of chronic AF compared to a sub-sample of the general population.Methods: Fifty-two chronic AF patients aged (60.5 +/- 9.5, 33 males) and 32 control (aged 57.3 +/- 9.6, 15 males). All subjects were evaluated by a staff cardiologist for the presence of medical conditions and were referred for polysomnography. the differences between groups were analyzed by ANOVA for continuous variables, and by the Chi-square test for dichotomous variables. Statistical significance was established by alpha = 0.05.Results: There were no differences in age, gender, BMI, sedentarism, presence of hypertension, type 2 diabetes mellitus, abdominal circumference, systolic and diastolic blood pressure, and sleepiness scoring between groups. Despite similar BMI, AF patients had a higher neck circumference compared to control group (39.9 cm versus 37.7 cm, p = 0.01) and the AF group showed higher percentage time of stage 1 NREM sleep (6.4% versus 3.9%. p = 0.03).Considering a cut-off value for AHI >= 10 per hour of sleep, the AF group had a higher frequency of OSA compared to the control group (81.6%, versus 60%, p = 0.03). All the oxygen saturation parameters were significantly worse ill the AF group, which had lower SaO(2) nadir (81.9% versus 85.3%, p = 0.0 1) and mean SaO(2) (93.4% versus 94.3%, p = 0.02), and a longer period of time below 90% (26.4 min versus 6.7 min, p = 0.05).Conclusion: Sleep-disordered breathing is more frequent in chronic persistent and permanent AF patients than in age-matched community dwelling subjects. (c) 2007 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, Sleep Inst, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Cardiol Sect, São Paulo, Brazil
dc.description.affiliationStanford Univ, Dept Psychiat, Sleep Disorders Ctr, Stanford, CA 94305 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, Sleep Inst, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Cardiol Sect, São Paulo, Brazil
dc.description.provenanceMade available in DSpace on 2016-01-24T13:52:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-02-01en
dc.description.sourceWeb of Science
dc.description.sponsorshipAFIP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent212-216
dc.identifierhttps://dx.doi.org/10.1016/j.sleep.2007.12.007
dc.identifier.citationSleep Medicine. Amsterdam: Elsevier B.V., v. 10, n. 2, p. 212-216, 2009.
dc.identifier.doi10.1016/j.sleep.2007.12.007
dc.identifier.issn1389-9457
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/31300
dc.identifier.wosWOS:000264683300010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofSleep Medicine
dc.rightsAcesso restrito
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectAtrial fibrillationen
dc.subjectSleep apneaen
dc.subjectSleep-disordered breathingen
dc.titleSleep-disordered breathing and chronic atrial fibrillationen
dc.typeArtigo
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