Prevalence and quality of life and sleep in children and adolescents with restless legs syndrome/Willis-Ekbom disease

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dc.citation.volume30
dc.contributor.authorSander, Heidi Haueisen
dc.contributor.authorEckeli, Alan Luiz
dc.contributor.authorPassos, Afonso Diniz Costa
dc.contributor.authorAzevedo, Leila
dc.contributor.authordo Prado, Lucila Bizari Fernandes [UNIFESP]
dc.contributor.authorFernandes, Regina Maria Franca
dc.coverageAmsterdam
dc.date.accessioned2020-07-17T14:03:07Z
dc.date.available2020-07-17T14:03:07Z
dc.date.issued2017
dc.description.abstractObjective: To estimate the prevalence of restless legs syndrome/Willis-Ekbom disease (RLS/WED) and its impact on sleep and quality of life in children and adolescents. Methods: This was a cross-sectional study conducted in the Municipality of Cassia dos Coqueiros, Brazil. Participants included 383 children and adolescents 5-17 years of age. A comparison group was randomly matched by gender and age with the RLS/WED-affected individuals, pairing one by one. Results: Interviews were conducted for 383 individuals by a neurologist experienced in sleep medicine. RLS/WED was diagnosed using the essential clinical criteria for definitive RLS/WED in children recommended by the International Restless Legs Syndrome Study Group. Sleep and quality of life were evaluated using the Sleep Behavior Questionnaire (SBQ) and the Health-related Quality of Life Questionnaire ePediatric Quality of Life Inventory (PedsQL). Comparisons were established with a group of randomly selected individuals without RLS/WED, matched by age and gender (control group). The prevalence of RLS/WED symptoms that manifested at least twice a week was 1.9%. The average age of children with RLS/WED was higher compared to the general population (11.5 +/- 2.3 vs 9.9 +/- 2.5, p < 0.005). A family history of RLS/WED was detected in 90.9% of the patients. The scores obtained by SBQ were higher (53.9 +/- 9.4 vs 47.6 +/- 10.9, p < 0.047), whereas the scores achieved by PedsQL were lower (69.8 +/- 14.8 vs 81.9 +/- 10.4, p < 0.003) in children with RLS/WED compared to controls. Conclusion: The prevalence of RLS/WED symptoms manifested at least twice in the preceding week was 1.9% in children and adolescents. Worsened sleep and quality of life were observed in the study. (C) 2016 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Sao Paulo, Fac Med, Dept Neurosci & Behav Sci, Div Neurol, Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med, Dept Social Med, Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.description.sponsorshipIDFAPESP: 08/57325-0
dc.format.extent204-209
dc.identifierhttp://dx.doi.org/10.1016/j.sleep.2016.10.014
dc.identifier.citationSleep Medicine. Amsterdam, v. 30, p. 204-209, 2017.
dc.identifier.doi10.1016/j.sleep.2016.10.014
dc.identifier.issn1389-9457
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55176
dc.identifier.wosWOS:000396883200036
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofSleep Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectRestless legs syndromeen
dc.subjectWillis-Ekbom diseaseen
dc.subjectChildrenen
dc.subjectEpidemiologyen
dc.subjectSleep qualityen
dc.subjectQuality of lifeen
dc.titlePrevalence and quality of life and sleep in children and adolescents with restless legs syndrome/Willis-Ekbom diseaseen
dc.typeinfo:eu-repo/semantics/article
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