Expression of behavioral sensitization to ethanol is increased by energy drink administration

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dc.contributor.authorFerreira, Sionaldo Eduardo [UNIFESP]
dc.contributor.authorAbrahao, Karina Possa [UNIFESP]
dc.contributor.authorSouza-Formigoni, Maria Lucia Oliveira de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:34:18Z
dc.date.available2016-01-24T14:34:18Z
dc.date.issued2013-09-01
dc.description.abstractAlcohol abuse and dependence are important medical, social and economical problems, affecting millions of people. A relatively recent habit among young people is mixing alcohol with energy drinks (ED), in spite of the risks involved may be higher than those associated with alcohol consumption alone. the mixture of alcohol and energy drinks, both with stimulant properties, may alter the perception of intoxication and could lead individuals to believe they are less drunk and can drink more or for longer periods of time. in animals, the repeated administration of ethanol can lead to a progressive increase of the locomotor stimulant effect, known as behavioral sensitization, a drug-dependent behavioral plasticity associated with vulnerability to addiction. As well as for addiction, there are clear individual differences in the level of sensitization to ethanol among species and even among individuals from the same strain. the present study assessed how ED affects the expression of ethanol sensitization. Female mice chronically treated with ethanol (2.4 g/kg) were classified as low-sensitized or high-sensitized. Two days later, different groups of mice were submitted to saline + water, ethanol + water or ethanol + ED systemic challenges. As expected, only the high-sensitized group expressed clear sensitization after ethanol administration. However, the administration of ethanol + ED triggered the sensitization expression in the low-sensitized group. These data indicate that the combined use of ED and ethanol can potentiate the stimulant and, consequently, the reward effects of ethanol in previously treated mice. If a similar process occurs in human beings, the use of ED can increase the risk of developing alcohol abuse or dependence. (C) 2013 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Ps Biol, Esco Paulista Med, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Ps Biol, Esco Paulista Med, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: FAPESP 02/04191-0
dc.format.extent245-248
dc.identifierhttp://dx.doi.org/10.1016/j.pbb.2013.07.014
dc.identifier.citationPharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 110, p. 245-248, 2013.
dc.identifier.doi10.1016/j.pbb.2013.07.014
dc.identifier.fileWOS000327112200032.pdf
dc.identifier.issn0091-3057
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36662
dc.identifier.wosWOS:000327112200032
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectEthanolen
dc.subjectEnergy drinken
dc.subjectLocomotor sensitizationen
dc.subjectIndividual variabilityen
dc.titleExpression of behavioral sensitization to ethanol is increased by energy drink administrationen
dc.typeinfo:eu-repo/semantics/article
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