The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats

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dc.citation.issue7]
dc.citation.volume32]
dc.contributor.authorRibeiro de Oliveira, Teresinha Regina [UNIFESP]
dc.contributor.authorde Oliveira, Geraldo Ferreira
dc.contributor.authorSimoes, Ricardo Santos [UNIFESP]
dc.contributor.authorTikazawa, Eduardo Hiroshi
dc.contributor.authorMonteiro, Hugo Pequeno [UNIFESP]
dc.contributor.authorFagundes, Djalma Jose [UNIFESP]
dc.contributor.authorTaha, Murched Omar [UNIFESP]
dc.coverageSao Paulo
dc.date.accessioned2020-06-26T16:30:27Z
dc.date.available2020-06-26T16:30:27Z
dc.date.issued2017
dc.description.abstractPurpose: To investigate the role of ischemic preconditioning (IPC) and pentoxifylline (PTX) in intestinal mucosa ischemia/reperfusion injury (IR). Methods: Thirty rats were assigned to 5 groups (N= 6): (CG): no clamping of the superior mesenteric artery (90 min.)en
dc.description.abstract(IR-SS): saline + ischemia (30 min.) + reperfusion (60 min.)en
dc.description.abstract(IRPTX): PTX + ischemia (30min.) + reperfusion (60 min.)en
dc.description.abstract(IPC-IR-SS): 5 min. of ischemia + 5 minutes of reperfusion (IPC) + saline + ischemia (30 min.) + reperfusion (60 min.)en
dc.description.abstract(IPC-IR-PTX): 5 min. of ischemia + 5 min. of reperfusion (IPC) + PTX + 30 min. of I + 60 minutes of R. Results: The IR-PTX, IPC-IR-SS and IPC-IR-PTX groups had significantly lower scores of mucosa damage than the IR-SS group. IR-PTX group showed higher scores than the IPC-IR-PTX group, in accordance with the hypothesis of a favorable effect of IPC alone or in association with PTX. Additionally, IPC-IR-SS had a higher damage score than the IPC-IR-PTX. The villi height and crypt depth were similar in all groups. The villi height in the IR-SS was significantly lower. Conclusion: Ischemic preconditioning or pentoxifylline alone protect the intestinal mucosa from ischemia/reperfusion injury. However, they do not have a synergistic effect when applied together.en
dc.description.affiliationUFGD, Sch Hlth Sci, Dourados, MS, Brazil
dc.description.affiliationUniv Sao Paulo UNIFESP, Dept Morfol & Genet, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Estadual Campinas UNICAMP, Sch Med, Dept Publ Hlth, Publ Hlth, Campinas, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biochem, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Surg, Div Surg Tech & Expt Surg, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Sao Paulo UNIFESP, Dept Morfol & Genet, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biochem, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Surg, Div Surg Tech & Expt Surg, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipUFGD, Ministerio da Educacao do Brasil
dc.description.sponsorshipIDUFGD, Ministerio da Educacao do Brasil
dc.format.extent559-567
dc.identifierhttp://dx.doi.org/10.1590/s0102-865020170070000007]
dc.identifier.citationActa Cirurgica Brasileira. Sao Paulo, v. 32, n. 7, p. 559-567, 2017.
dc.identifier.doi10.1590/s0102-865020170070000007
dc.identifier.fileS0102-86502017000700559.pdf
dc.identifier.issn0102-8650
dc.identifier.scieloS0102-86502017000700559
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53550
dc.identifier.wosWOS:000407368300007
dc.language.isoeng
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsACESSO ABERTO
dc.subjectIschemic Preconditioningen
dc.subjectPentoxifyllineen
dc.subjectIschemiaen
dc.subjectReperfusion Injuryen
dc.subjectIntestinesen
dc.subjectRatsen
dc.titleThe role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of ratsen
dc.typeArtigo
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