Post-operative progress of patients with Rasmussen's encephalitis who have undergone hemispherotomy surgery

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dc.contributor.authorGarofalo-Gomez, Nicolas
dc.contributor.authorHamad, Ana Paula Andrade [UNIFESP]
dc.contributor.authorCenteno, Ricardo Silva [UNIFESP]
dc.contributor.authorFerrari, Taissa Pinheiro Fernandes [UNIFESP]
dc.contributor.authorCarrete Junior, Henrique [UNIFESP]
dc.contributor.authorCaboclo, Luis Otavio Sales Ferreira [UNIFESP]
dc.contributor.authorYacubian, Elza Márcia Targas [UNIFESP]
dc.contributor.institutionInst Neurol & Neurocirugia
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T11:54:26Z
dc.date.available2018-06-18T11:54:26Z
dc.date.issued2013-02-16
dc.description.abstractIntroduction. Rasmussen's encephalitis (RE) is a progressive pathology affecting the brain that causes unilateral hemispheric atrophy, neurological dysfunction and refractory epilepsy. Hemispherotomy is considered the most effective treatment today, but some cases present certain peculiarities that can seriously affect the decision to go ahead with this procedure.Aims. To evaluate the post-operative progress made by children with RE who have undergone hemispherotomy surgery, and who, in the pre-operative assessment, presented certain characteristics that complicated the decision to perform surgery.Patients and methods. The sample selected for study consisted of the cases of RE attended in the Hospital Sao Paulo between 2003 and 2012 who, in the pre-surgery evaluation, presented clinical, electroencephalographic or neuroimaging evidence of involvement of both brain hemispheres, compromise of the dominant brain hemisphere, absence of severe neurological deficit and absence of criteria for refractory epilepsy and atypical crises. The post-operative assessment of the epileptic seizures was evaluated using the Engel scale; motor function was analysed with the Gross Motor Function Classification System and Manual Ability Classification System scales, and language was evaluated clinically.Results. Six cases were selected (four girls), with a mean age at clinical onset of 3.3 +/- 1.2 years (range: 2-7 years) and a mean age at hemispherotomy of 6.7 years (range: 2.3-16.5 years). The mean post-surgery follow-up time was three years (range: 0.5-7.2 years). In the post-surgery evaluation of the epileptic seizures, four cases were classified as Engel class I (66%); there was some improvement in motor functioning in five of them, and language improved in all cases.Conclusions. Hemispherotomy must be considered an efficient option for treatment in children with RE.en
dc.description.affiliationInst Neurol & Neurocirugia, Dept Neuropediat, Havana 10400, Cuba
dc.description.affiliationUniv Fed Sao Paulo, Dept Neurol & Neurocirugia, Hosp Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Diagnost Imagen, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Neurol & Neurocirugia, Hosp Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Diagnost Imagen, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent214-219
dc.identifierhttp://www.neurologia.com/sec/resumen.php?or=web&i=e&id=2012419
dc.identifier.citationRevista De Neurologia. Barcelona: Revista De Neurologia, v. 56, n. 4, p. 214-219, 2013.
dc.identifier.issn0210-0010
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/45472
dc.identifier.wosWOS:000315747200004
dc.language.isospa
dc.publisherRevista De Neurologia
dc.relation.ispartofRevista De Neurologia
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectChildrenen
dc.subjectEpilepsyen
dc.subjectHemispherotomyen
dc.subjectLanguageen
dc.subjectMotor functionen
dc.subjectProgressen
dc.subjectQuality of lifeen
dc.subjectRasmussen's encephalitisen
dc.titlePost-operative progress of patients with Rasmussen's encephalitis who have undergone hemispherotomy surgeryen
dc.titleEvolución posquirúrgica en pacientes con encefalitis de Rasmussen operados por hemisferotomíaes
dc.typeinfo:eu-repo/semantics/article
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