GLYCOSAMINOGLYCANS AND PROTEOGLYCANS IN PALMAR FASCIA OF PATIENTS WITH DUPUYTREN

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dc.citation.issue2
dc.citation.volume24
dc.contributor.authorHirai Nascimento, Priscilla Carneiro [UNIFESP]
dc.contributor.authorKobayashi, Elsa Yoko [UNIFESP]
dc.contributor.authorde Saboya Lenzi, Luiz Guilherme [UNIFESP]
dc.contributor.authorGomes dos Santos, Joao Baptista [UNIFESP]
dc.contributor.authorNader, Helena Bonciani [UNIFESP]
dc.contributor.authorFaloppa, Flavio [UNIFESP]
dc.coverageSao Paulo Sp
dc.date.accessioned2020-08-21T17:00:08Z
dc.date.available2020-08-21T17:00:08Z
dc.date.issued2016
dc.description.abstractObjective: To evaluate and compare the behavior of glycosaminoglycans (GAGs) in Dupuytren disease (DD). Methods: This is an experimental study with 23 patients diagnosed with DD. Tissue collected through fasciectomy with incision type Brunner or McCash were evaluated by electrophoresis for identification of GAGs. The quantification was carried out by immunofluorescence and dosage of proteins for different types of glycosaminoglycans. The results were expressed in percentage and statistically evaluated. Results: A significant increase was observed through eletrophoresis in GAGs, as compared to the control (p<0.05). Immunofluorescence of hyaluronic acid was reduced (23 times) when compared to the control (p<0.0001). Conclusion: An increase of sulfated GAGs in Dupuytren's disease, mainly dermatan sulfate, was evident from our results, as well as a pronounced decrease of hyaluronic acid in the palmar aponeurosis from the same patients.en
dc.description.affiliationUniv Fed Sao Paulo Unifesp, Escola Paulista Med, Dept Orthoped & Traumatol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Orthoped & Traumatol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, Escola Paulista Med, Dept Orthoped & Traumatol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Orthoped & Traumatol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent98-101
dc.identifierhttp://dx.doi.org/10.1590/1413-785220162402154342
dc.identifier.citationActa Ortopedica Brasileira. Sao Paulo Sp, v. 24, n. 2, p. 98-101, 2016.
dc.identifier.doi10.1590/1413-785220162402154342
dc.identifier.fileS1413-78522016000200098-en.pdf
dc.identifier.issn1413-7852
dc.identifier.scieloS1413-78522016000200098
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57881
dc.identifier.wosWOS:000372326500008
dc.language.isoeng
dc.publisherAtha Comunicacao & Editora
dc.relation.ispartofActa Ortopedica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDupuytren contractureen
dc.subjectGlycosaminoglycansen
dc.subjectProteoglycansen
dc.subjectFasciaen
dc.titleGLYCOSAMINOGLYCANS AND PROTEOGLYCANS IN PALMAR FASCIA OF PATIENTS WITH DUPUYTRENen
dc.typeinfo:eu-repo/semantics/article
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