Total renal denervation reduces sympathoexcitation to different target organs in a model of chronic kidney disease

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dc.citation.volume204
dc.contributor.authorVeiga, Glaucia L.[UNIFESP]
dc.contributor.authorNishi, Erika E.[UNIFESP]
dc.contributor.authorEstrela, Heder F.[UNIFESP]
dc.contributor.authorLincevicius, Gisele S.[UNIFESP]
dc.contributor.authorGomes, Guiomar N.
dc.contributor.authorSimoes Sato, Alex Y.[UNIFESP]
dc.contributor.authorCampos, Ruy R.[UNIFESP]
dc.contributor.authorBergamaschi, Cassia T.[UNIFESP]
dc.coverageAmsterdam
dc.date.accessioned2020-07-13T11:53:25Z
dc.date.available2020-07-13T11:53:25Z
dc.date.issued2017
dc.description.abstractIt is known that increased sympathetic nerve activity in chronic kidney disease (CKD) progressively worsens kidney function and hypertension. We tested the hypothesis that total renal denervation contributes to reduce sympathetic activation to different beds and improves renal function in 5/6 nephrectomy model of CKD in male Wistar rats. After eight weeks of 5/6 nephrectomy surgery there was an increase in mean arterial pressure (CKD 179 +/- 22 mm Hg, n = 6 vs. control animals 108 +/- 9en
dc.description.abstractp < 0.05, n = 6) with no changes in heart rate (HR). Sympathetic nerve activity was increased at different levels to the remaining kidney, splanchnic and lumbar beds compared to control (CTL) group (CKD rSNA: 150 +/- 50, n = 9 vs. CTL 96 +/- 15, n = 9en
dc.description.abstractCKD sSNA: 129 +/- 51, n = 5 vs. CTL 34 +/- 14, n = 6en
dc.description.abstractCKD ISNA: 203 +/- 35, n = 8 vs. CTL 146 +/- 21, spikes/s, n = 7, p < 0.05). Three weeks after total renal denervation (DNX) MAP was normalized in the CKD rats (124 +/- 19 mm Hg, n = 5, p < 0.05), with no change in HR. The ISNA was normalized (151 +/- 40, n = 5, vs. CKD 203 +/- 35 spikes/s, n = 8) and sSNA was decreased in 49% (64 +/- 34, n = 5 vs. CKD 129 +/- 51 spikes/s, n = 5, p < 0.05). Renal function, assessed by creatinine plasma levels was improved after renal denervation (CKD 1.50 +/- 0.64, n = 8en
dc.description.abstractvs. CKD + DNX 0.82 +/- 0.22 mg/mL, n = 8, p < 0.05). These findings demonstrate that renal nerves contribute to the maintenance of hypertension in CKD by increasing sympathoexcitation to other beds. (C) 2016 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Physiol, Cardiovasc Div, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Physiol, Div Renal, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Physiol, Cardiovasc Div, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Physiol, Div Renal, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation
dc.description.sponsorshipCNPq fellowships
dc.description.sponsorshipFAPESP
dc.description.sponsorshipCAPES-PNPD Postdoctoral Fellowships
dc.description.sponsorshipIDFAPESP: 2013/22522-9
dc.description.sponsorshipIDFAPESP: 2013/23741-6
dc.format.extent81-87
dc.identifierhttp://dx.doi.org/10.1016/j.autneu.2016.11.006
dc.identifier.citationAutonomic Neuroscience-Basic & Clinical. Amsterdam, v. 204, p. 81-87, 2017.
dc.identifier.doi10.1016/j.autneu.2016.11.006
dc.identifier.issn1566-0702
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54616
dc.identifier.wosWOS:000400219400010
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofAutonomic Neuroscience-Basic & Clinical
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectChronic kidney diseaseen
dc.subjectHypertensionen
dc.subjectSympathetic activityen
dc.subjectRenal afferent activationen
dc.subjectRenal denervationen
dc.titleTotal renal denervation reduces sympathoexcitation to different target organs in a model of chronic kidney diseaseen
dc.typeinfo:eu-repo/semantics/article
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