Association of urinary 90 kDa angiotensin- converting enzyme with family history of hypertension and endothelial function in normotensive individuals

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dc.contributor.authorTeixeira, A.m.s. [UNIFESP]
dc.contributor.authorPlavnik, Frida Liane [UNIFESP]
dc.contributor.authorFernandes, Fernanda Barrinha [UNIFESP]
dc.contributor.authorMarson, Odair [UNIFESP]
dc.contributor.authorChristofalo, Dejaldo Marcos de Jesus [UNIFESP]
dc.contributor.authorAjzen, Sergio Aron [UNIFESP]
dc.contributor.authorSesso, Ricardo de Castro Cintra [UNIFESP]
dc.contributor.authorFranco, Maria do Carmo Pinho [UNIFESP]
dc.contributor.authorCasarini, Dulce Elena [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:38:33Z
dc.date.available2015-06-14T13:38:33Z
dc.date.issued2008-05-01
dc.description.abstractWe described angiotensin-I-converting enzyme (ACE) isoforms with molecular masses of 190, 90, and 65 kDa in the urine of normotensive offspring of hypertensive subjects. Since they did not appear in equal amounts, we suggested that 90 kDa ACE might be a marker for hypertension. We evaluated the endothelial response in normotensive offspring with or without family history of hypertension and its association with the 90 kDa ACE in urine. Thirty-five normotensive subjects with a known family history of hypertension and 20 subjects without a family history of hypertension, matched for age, sex, body weight, and blood pressure, were included in the study. Endothelial function was assessed by ultrasound and a sample of urine was collected for determination of ACE isoforms. In the presence of a family history of hypertension and detection of 90 kDa ACE, we noted a maximal flow mediated dilation of 12.1 ± 5.0 vs 16.1 ± 6.0% in those without a previous history of hypertension and lacking urinary 90 kDa ACE (P < 0.05). In subjects with a family history of hypertension and presenting 90 kDa ACE, there were lower levels of HDL-cholesterol (P < 0.05) and higher levels of triglycerides (P < 0.05). Subjects with 90 kDa ACE irrespective of hypertensive history presented a trend for higher levels of triglycerides and HDL-cholesterol (P = 0.06) compared to subjects without 90 kDa ACE. Our data suggest that the 90 kDa ACE may be a marker for hypertension which may be related to the development of early atherosclerotic changes.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Medicina
dc.description.affiliationFundação Oswaldo Ramos Universidade Federal de São Paulo (UNIFESP) e Hospital do Rim e Hipertensão Departamento de Radiologia
dc.description.affiliationUnifespUNIFESP, EPM, Depto. de Medicina
dc.description.affiliationUnifespFundação Oswaldo Ramos UNIFESP, e Hospital do Rim e Hipertensão Depto. de Radiologia
dc.description.sourceSciELO
dc.format.extent351-356
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2008005000017
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 5, p. 351-356, 2008.
dc.identifier.doi10.1590/S0100-879X2008005000017
dc.identifier.fileS0100-879X2008000500002.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2008000500002
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/4374
dc.identifier.wosWOS:000258764000002
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsAcesso aberto
dc.subjectEndothelial dysfunctionen
dc.subjectAngiotensin-I-converting enzymeen
dc.subjectHypertensionen
dc.subjectNormotensionen
dc.subjectN-domain angiotensin- converting enzymeen
dc.titleAssociation of urinary 90 kDa angiotensin- converting enzyme with family history of hypertension and endothelial function in normotensive individualsen
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