Fungi that Infect Humans

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dc.citation.issue3]
dc.citation.volume5]
dc.contributor.authorKohler, Julia R.
dc.contributor.authorHube, Bernhard
dc.contributor.authorPuccia, Rosana [UNIFESP]
dc.contributor.authorCasadevall, Arturo
dc.contributor.authorPerfect, John R.
dc.coverageWashington
dc.date.accessioned2020-06-26T16:30:39Z
dc.date.available2020-06-26T16:30:39Z
dc.date.issued2017
dc.description.abstractFungi must meet four criteria to infect humans: growth at human body temperatures, circumvention or penetration of surface barriers, lysis and absorption of tissue, and resistance to immune defenses, including elevated body temperatures. Morphogenesis between small round, detachable cells and long, connected cells is the mechanism by which fungi solve problems of locomotion around or through host barriers. Secretion of lytic enzymes, and uptake systems for the released nutrients, are necessary if a fungus is to nutritionally utilize human tissue. Last, the potent human immune system evolved in the interaction with potential fungal pathogens, so few fungi meet all four conditions for a healthy human host. Paradoxically, the advances of modern medicine have made millions of people newly susceptible to fungal infections by disrupting immune defenses. This article explores how different members of four fungal phyla use different strategies to fulfill the four criteria to infect humans: the Entomophthorales, the Mucorales, the Ascomycota, and the Basidiomycota. Unique traits confer human pathogenic potential on various important members of these phyla: pathogenic Onygenales comprising thermal dimorphs such as Histoplasma and Coccidioidesen
dc.description.abstractthe Cryptococcus spp. that infect immunocompromised as well as healthy humansen
dc.description.abstractand important pathogens of immunocompromised patients-Candida, Pneumocystis, and Aspergillus spp. Also discussed are agents of neglected tropical diseases important in global health such as mycetoma and paracoccidiomycosis and common pathogens rarely implicated in serious illness such as dermatophytes. Commensalism is considered, as well as parasitism, in shaping genomes and physiological systems of hosts and fungi during evolution.en
dc.description.affiliationBoston Childrens Hosp, Div Infect Dis, Boston, MA 02115 USA
dc.description.affiliationHans Knoell Inst Jena HKI, Leibniz Inst Nat Prod Res & Infect Biol, Dept Microbial Pathogen Mech, Jena, Germany
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, Disciplina Biol Celular, Sao Paulo, Brazil
dc.description.affiliationJohns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA
dc.description.affiliationDuke Univ, Med Ctr, Div Infect Dis, Durham, NC 27710 USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, Disciplina Biol Celular, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1128/microbiolspec.FUNK-0014-2016]
dc.identifier.citationMicrobiology Spectrum. Washington, v. 5, n. 3, p. -, 2017.
dc.identifier.doi10.1128/microbiolspec.FUNK-0014-2016
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53689
dc.identifier.wosWOS:000406813500012
dc.language.isoeng
dc.publisherAmer Soc Microbiology
dc.relation.ispartofMicrobiology Spectrum
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titleFungi that Infect Humansen
dc.typeinfo:eu-repo/semantics/article
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