Mechanistic Insights into the Anti-angiogenic Activity of Trypanosoma cruzi Protein 21 and its Potential Impact on the Onset of Chagasic Cardiomyopathy

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dc.citation.volume7
dc.contributor.authorTeixeira, Samuel Cota
dc.contributor.authorLopes, Daiana Silva
dc.contributor.authorCirilo Gimenes, Sarah Natalie
dc.contributor.authorTeixeira, Thaise Lara
dc.contributor.authorda Silva, Marcelo Santos
dc.contributor.authorBrgido, Rebecca Tavares e Silva
dc.contributor.authorCordero da Luz, Felipe Andres
dc.contributor.authorda Silva, Aline Alves
dc.contributor.authorSilva, Makswell Almeida
dc.contributor.authorFlorentino, Pilar Veras [UNIFESP]
dc.contributor.authorBrigido Tavares, Paula Cristina
dc.contributor.authordos Santos, Marlus Alves
dc.contributor.authorRodrigues Avila, Veridiana de Melo
dc.contributor.authorBarbosa Silva, Marcelo Jose
dc.contributor.authorElias, Maria Carolina
dc.contributor.authorMortara, Renato Arruda [UNIFESP]
dc.contributor.authorda Silva, Claudio Vieira
dc.coverageLondon
dc.date.accessioned2020-07-17T14:02:38Z
dc.date.available2020-07-17T14:02:38Z
dc.date.issued2017
dc.description.abstractChronic chagasic cardiomyopathy (CCC) is arguably the most important form of the Chagas Disease, caused by the intracellular protozoan Trypanosoma cruzien
dc.description.abstractit is estimated that 10-30% of chronic patients develop this clinical manifestation. The most common and severe form of CCC can be related to ventricular abnormalities, such as heart failure, arrhythmias, heart blocks, thromboembolic events and sudden death. Therefore, in this study, we proposed to evaluate the anti-angiogenic activity of a recombinant protein from T. cruzi named P21 (rP21) and the potential impact of the native protein on CCC. Our data suggest that the anti-angiogenic activity of rP21 depends on the protein's direct interaction with the CXCR4 receptor. This capacity is likely related to the modulation of the expression of actin and angiogenesis-associated genes. Thus, our results indicate that T. cruzi P21 is an attractive target for the development of innovative therapeutic agents against CCC.en
dc.description.affiliationUniv Fed Uberlandia, Inst Ciencias Biomed, Dept Imunol, Lab Tripanosomatideos, Uberlandia, MG, Brazil
dc.description.affiliationUniv Fed Uberlandia, Inst Genet & Bioquim, Lab Bioquim & Toxinas Animais, Uberlandia, MG, Brazil
dc.description.affiliationCeTICS, Inst Butantan, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Uberlandia, Fac Med, Centro Referencia Nacl Dermatol Sanitaria Hanseni, Lab Patol Mol & Biotecnol, Uberlandia, MG, Brazil
dc.description.affiliationUniv Fed Uberlandia, Inst Ciencias Biomed, Dept Immunol, Lab Osteoimunol & Imunol Tumores, Uberlandia, MG, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Departamento Microbiol Imunol Parasitol, BR-05508 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Departamento Microbiol Imunol Parasitol, BR-05508 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipUniv Fed Sao Paulo, Escola Paulista Med, Departamento Microbiol Imunol Parasitol, BR-05508 Sao Paulo, SP, Brazil
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1038/srep44978
dc.identifier.citationScientific Reports. London, v. 7, p. -, 2017.
dc.identifier.doi10.1038/srep44978
dc.identifier.fileWOS000396861900002.pdf
dc.identifier.issn2045-2322
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54917
dc.identifier.wosWOS:000396861900002
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofScientific Reports
dc.rightsAcesso aberto
dc.titleMechanistic Insights into the Anti-angiogenic Activity of Trypanosoma cruzi Protein 21 and its Potential Impact on the Onset of Chagasic Cardiomyopathyen
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