Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis Fundamentals Of Care for UveitiS (FOCUS) Initiative

Página do item simplificado
dc.citation.issue5
dc.citation.volumev. 125
dc.contributor.authorDick, Andrew D.
dc.contributor.authorRosenbaum, James T.
dc.contributor.authorAl-Dhibi, Hassan A.
dc.contributor.authorBelfort, Rubens, Jr. [UNIFESP]
dc.contributor.authorBrezin, Antoine P.
dc.contributor.authorChee, Soon Phaik
dc.contributor.authorDavis, Janet L.
dc.contributor.authorRamanan, Athimalaipet V.
dc.contributor.authorSonoda, Koh-Hei
dc.contributor.authorCarreno, Ester
dc.contributor.authorNascimento, Heloisa [UNIFESP]
dc.contributor.authorSalah, Sawsen
dc.contributor.authorSalek, Sherveen
dc.contributor.authorSiak, Jay
dc.contributor.authorSteeples, Laura
dc.coverageNew York
dc.date.accessioned2020-07-20T16:30:55Z
dc.date.available2020-07-20T16:30:55Z
dc.date.issued2018
dc.description.abstractTopic: An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in the era of biologics. Clinical Relevance: The availability of biologic agents for the treatment of human eye disease has altered practice patterns for the management of noninfectious uveitis. Current guidelines are insufficient to assure optimal use of noncorticosteroid systemic immunomodulatory agents. Methods: An international expert steering committee comprising 9 uveitis specialists (including both ophthalmologists and rheumatologists) identified clinical questions and, together with 6 bibliographic fellows trained in uveitis, conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol systematic review of the literature (English language studies from January 1996 through June 2016en
dc.description.abstractMedline [OVID], the Central Cochrane library, EMBASE, CINAHL, SCOPUS, BIOSIS, and Web of Science). Publications included randomized controlled trials, prospective and retrospective studies with sufficient follow-up, case series with 15 cases or more, peer-reviewed articles, and hand-searched conference abstracts from key conferences. The proposed statements were circulated among 130 international uveitis experts for review. A total of 44 globally representative group members met in late 2016 to refine these guidelines using a modified Delphi technique and assigned Oxford levels of evidence. Results: In total, 10 questions were addressed resulting in 21 evidence-based guidance statements covering the following topics: when to start noncorticosteroid immunomodulatory therapy, including both biologic and nonbiologic agentsen
dc.description.abstractwhat data to collect before treatmenten
dc.description.abstractwhen to modify or withdraw treatmenten
dc.description.abstracthow to select agents based on individual efficacy and safety profilesen
dc.description.abstractand evidence in specific uveitic conditions. Shared decision-making, communication among providers and safety monitoring also were addressed as part of the recommendations. Pharmacoeconomic considerations were not addressed. Conclusions: Consensus guidelines were developed based on published literature, expert opinion, and practical experience to bridge the gap between clinical needs and medical evidence to support the treatment of patients with noninfectious uveitis with noncorticosteroid immunomodulatory agents. (C) 2018 by the American Academy of Ophthalmology.en
dc.description.affiliationUniv Bristol, Sch Clin Sci, Ophthalmol, Bristol, Avon, England
dc.description.affiliationUCL, Inst Ophthalmol, London, England
dc.description.affiliationUCL, Moorfields Eye Hosp, Biomed Res Ctr, NIHR, London, England
dc.description.affiliationUCL, Inst Ophthalmol, London, England
dc.description.affiliationLegacy Devers Eye Inst, Portland, OR USA
dc.description.affiliationOregon Hlth & Sci Univ, Dept Ophthalmol, Portland, OR 97201 USA
dc.description.affiliationOregon Hlth & Sci Univ, Dept Med, Portland, OR 97201 USA
dc.description.affiliationOregon Hlth & Sci Univ, Dept Cell Biol, Portland, OR 97201 USA
dc.description.affiliationKing Khalid Eye Specialist Hosp, Div Vitreoretinal Surg & Uveitis, Riyadh, Saudi Arabia
dc.description.affiliationUniv Fed Sao Paulo, Paulista Sch Med, Dept Ophthalmol & Visual Sci, Sao Paulo, Brazil
dc.description.affiliationVis Inst, Sao Paulo, Brazil
dc.description.affiliationUniv Paris 05, Hop Cochin, Serv Ophtalmol, Paris, France
dc.description.affiliationSingapore Natl Eye Ctr, Ocular Inflammat & Immunol Serv, Singapore, Singapore
dc.description.affiliationSingapore Eye Res Inst, Singapore, Singapore
dc.description.affiliationNatl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore
dc.description.affiliationDuke Natl Univ, Singapore Med Sch, Ophthalmol & Visual Sci Acad Clin Program, Singapore, Singapore
dc.description.affiliationUniv Miami, Miller Sch Med, Bascom Palmer Eye Inst, Miami, FL 33136 USA
dc.description.affiliationUniv Hosp Bristol NHS Fdn Trust, Pediat Rheumatol, Bristol, Avon, England
dc.description.affiliationKyushu Univ, Grad Sch Med Sci, Dept Ophthalmol, Fukuoka, Japan
dc.description.affiliationUniv Hosp Bristol NHS Fdn Trust, Bristol Eye Hosp, Ophthalmol, Bristol, Avon, England
dc.description.affiliationUniv Fed Sao Paulo, Uveitis Serv, Sao Paulo, Brazil
dc.description.affiliationJohns Hopkins Univ, Sch Med, Wilmer Eye Inst, Baltimore, MD 21205 USA
dc.description.affiliationCent Manchester Univ Hosp, Manchester Royal Eye Hosp, Manchester, Lancs, England
dc.description.affiliationUniv Manchester, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England
dc.description.affiliationUnifespUniv Fed Sao Paulo, Paulista Sch Med, Dept Ophthalmol & Visual Sci, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Uveitis Serv, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAbbVie, Inc.
dc.description.sponsorshipFundamentals of Care for Uveitis Initiative National Faculty
dc.description.sponsorshipAbbVie
dc.format.extent757-773
dc.identifierhttp://dx.doi.org/10.1016/j.ophtha.2017.11.017
dc.identifier.citationOphthalmology. New York, v. 125, n. 5, p. 757-773, 2018.
dc.identifier.doi10.1016/j.ophtha.2017.11.017
dc.identifier.fileWOS000430558800029.pdf
dc.identifier.issn0161-6420
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55587
dc.identifier.wosWOS:000430558800029
dc.language.isoeng
dc.publisherElsevier Science Inc
dc.relation.ispartofOphthalmology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleGuidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis Fundamentals Of Care for UveitiS (FOCUS) Initiativeen
dc.typeinfo:eu-repo/semantics/review
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000430558800029.pdf
Tamanho:
606.73 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos