Lipid fingerprinting in women with early-onset preeclampsia: A first look

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dc.contributor.authorDe Oliveira, Leandro [UNIFESP]
dc.contributor.authorCamara, Niels Olsen S.
dc.contributor.authorBonetti, Tatiana [UNIFESP]
dc.contributor.authorLo Turco, Edson G. [UNIFESP]
dc.contributor.authorBertolla, Ricardo Pimenta [UNIFESP]
dc.contributor.authorMoron, Antonio F. [UNIFESP]
dc.contributor.authorSass, Nelson [UNIFESP]
dc.contributor.authorCotrim Guerreiro Da Silva, Ismael Dale [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionHosp Maternidade Vila Nova Cachoeirinha
dc.date.accessioned2016-01-24T14:27:25Z
dc.date.available2016-01-24T14:27:25Z
dc.date.issued2012-07-01
dc.description.abstractObjectives: the aim of this preliminary study was to characterize the plasma lipid profiling of women with preeclampsia.Design and methods: Plasma samples of 8 pregnant women with early-onset preeclampsia and 8 normal pregnant women were evaluated. Lipids were extracted from plasma using the Bligh-Dyer protocol. the extracts were subjected to MALDI-MS. Data matrix was exported for partial least squares discriminant analysis (PLS-DA) and a parameter VIP was employed to reflect the variable importance in the discriminant analysis. the major discriminant variables were selected and underwent to Mann-Whitney U test.Results: A total of 1290 ions were initially identified and twelve m/z signals were highlighted as the most important lipids for the discrimination of patients with preeclampsia. the identification of these differential lipids was carried out through Lipid Database Search.Conclusions: the main classes identified were glycerophosphocholines [GP01], glycerophosphoserines [GP03], glycerophosphoglycerols [GP04], glycosyldiradylglycerols [GL05] and glycerophosphates [GP10]. (C) 2012 the Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Obstet, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Lab Immunobiol Transplantat, BR-05508 São Paulo, Brazil
dc.description.affiliationHosp Maternidade Vila Nova Cachoeirinha, Lab Clin & Expt Invest, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Gynecol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Obstet, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Gynecol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent852-855
dc.identifierhttp://dx.doi.org/10.1016/j.clinbiochem.2012.04.012
dc.identifier.citationClinical Biochemistry. Oxford: Pergamon-Elsevier B.V., v. 45, n. 10-11, p. 852-855, 2012.
dc.identifier.doi10.1016/j.clinbiochem.2012.04.012
dc.identifier.issn0009-9120
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35054
dc.identifier.wosWOS:000305919400029
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofClinical Biochemistry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectPreeclampsiaen
dc.subjectLipidomicsen
dc.subjectInflammationen
dc.subjectFingerprintsen
dc.subjectLipidsen
dc.titleLipid fingerprinting in women with early-onset preeclampsia: A first looken
dc.typeinfo:eu-repo/semantics/article
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