Impact of antiretroviral resistance and virological failure on HIV-1 informational entropy

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dc.citation.issue4
dc.citation.volumev. 73
dc.contributor.authorLima, Elidamar Nunes de Carvalho [UNIFESP]
dc.contributor.authorPiqueira, Jose Roberto Castilho
dc.contributor.authorCamargo, Michelle [UNIFESP]
dc.contributor.authorGalinskas, Juliana [UNIFESP]
dc.contributor.authorSucupira, Maria Cecilia [UNIFESP]
dc.contributor.authorDiaz, Ricardo Sobhie [UNIFESP]
dc.coverageOxford
dc.date.accessioned2020-07-20T16:31:09Z
dc.date.available2020-07-20T16:31:09Z
dc.date.issued2018
dc.description.abstractObjectives: The present study investigated the relationship between genomic variability and resistance of HIV-1 sequences in protease (PR) and reverse transcriptase (RT) regions of the pol gene. In addition, we analysed the resistance among 651 individuals presenting antiretroviral virological failure, from 2009 to 2011, in the state of Sao Paulo, Brazil. Methods: The genomic variability was quantified by using informational entropy methods and the relationship between resistance and replicative fitness, as inferred by the residual viral load and CD4+ T cell count. Results: The number of antiretroviral schemes is related to the number of resistance mutations in the HIV-1 PR (alpha = 0.2511, P = 0.0003, R-2 = 0.8672) and the RT (alpha = 0.7892, P = 0.0001, R-2 = 0.9141). Increased informational entropy rate is related to lower levels of HIV-1 viral loads (alpha = -0.0121, P = 0.0471, R-2 = 0.7923), lower levels of CD4+ T cell counts (alpha = -0.0120, P = 0.0335, R-2 = 0.8221) and a higher number of antiretroviral resistance-related mutations. Conclusions: Less organized HIV genomes as inferred by higher levels of informational entropy relate to less competent host immune systems, lower levels of HIV replication and HIV genetic evolution as a consequence of antiretroviral resistance.en
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Paulista Sch Med, Div Infect Dis, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Engn, Telecommun & Control Engn Dept, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Paulista Sch Med, Div Infect Dis, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 2011/12156-0
dc.format.extent1054-1059
dc.identifierhttp://dx.doi.org/10.1093/jac/dkx508
dc.identifier.citationJournal Of Antimicrobial Chemotherapy. Oxford, v. 73, n. 4, p. 1054-1059, 2018.
dc.identifier.doi10.1093/jac/dkx508
dc.identifier.issn0305-7453
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55745
dc.identifier.wosWOS:000429019600030
dc.language.isoeng
dc.publisherOxford Univ Press
dc.relation.ispartofJournal Of Antimicrobial Chemotherapy
dc.rightsAcesso restrito
dc.titleImpact of antiretroviral resistance and virological failure on HIV-1 informational entropyen
dc.typeArtigo
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