Hippocampal-dependent memory in the plus-maze discriminative avoidance task: The role of spatial cues and CA1 activity

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dc.citation.volume304
dc.contributor.authorLeão, Anderson Henrique França Figueiredo
dc.contributor.authorMedeiros, André de Macêdo [UNIFESP]
dc.contributor.authorApolinário, Gênedy Karielly da Silva
dc.contributor.authorCabral, Alicia
dc.contributor.authorRibeiro, Alessandra Mussi [UNIFESP]
dc.contributor.authorBarbosa, Flavio Freitas
dc.contributor.authorSilva, Regina Helena [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.coverageAmsterdam
dc.date.accessioned2020-07-22T13:23:05Z
dc.date.available2020-07-22T13:23:05Z
dc.date.issued2016
dc.description.abstractThe plus-maze discriminative avoidance task (PMDAT) has been used to investigate interactions between aversive memory and an anxiety-like response in rodents. Suitable performance in this task depends on the activity of the basolateral amygdala, similar to other aversive-based memory tasks. However, the role of spatial cues and hippocampal-dependent learning in the performance of PMDAT remains unknown. Here, we investigated the role of proximal and distal cues in the retrieval of this task. Animals tested under misplaced proximal cues had diminished performance, and animals tested under both misplaced proximal cues and absent distal cues could not discriminate the aversive arm. We also assessed the role of the dorsal hippocampus (CA1) in this aversive memory task. Temporary bilateral inactivation of dorsal CA1 was conducted with muscimol (0.05 mu g, 0.1 mu g, and 0.2 mu g) prior to the training session. While the acquisition of the task was not altered, muscimol impaired the performance in the test session and reduced the anxiety-like response in the training session. We also performed a spreading analysis of a fluorophore-conjugated muscimol to confirm selective inhibition of CA1. In conclusion, both distal and proximal cues are required to retrieve the task, with the latter being more relevant to spatial orientation. Dorsal CM activity is also required for aversive memory formation in this task, and interfered with the anxiety-like response as well. Importantly, both effects were detected by different parameters in the same paradigm, endorsing the previous findings of independent assessment of aversive memory and anxiety like behavior in the PMDAT. Taken together, these findings suggest that the PMDAT probably requires an integration of multiple systems for memory formation, resembling an episodic-like memory rather than a pure conditioning behavior. Furthermore, the concomitant and independent assessment of emotionality and memory in rodents is relevant to elucidate how these memory systems interact during aversive memory formation. Thus, the PMDAT can be useful for studying hippocampal-dependent memory when it involves emotional content. (C) 2016 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Rio Grande do Norte, Dept Physiol, Memory Studies Lab, Natal, RN, Brazil
dc.description.affiliationUniv Fed Paraiba, Dept Psychol, Memory & Cognit Studies Lab, BR-58059900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pharmacol, Lab Behav Neurosci, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biosci, Lab Neurosci & Bioprospecting Nat Prod, Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pharmacol, Lab Behav Neurosci, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biosci, Lab Neurosci & Bioprospecting Nat Prod, Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt
dc.description.sponsorshipFundação de Apoio à Pesquisa do Estado do Rio Grande do Norte (FAPERN)pt
dc.description.sponsorshipPró-reitoria de Pesquisa da Universidade Federal do Rio Grande do Norte (PROPESQ/UFRN)pt
dc.format.extent24-33
dc.identifierhttps://dx.doi.org/10.1016/j.bbr.2016.02.012
dc.identifier.citationBehavioural Brain Research. Amsterdam, v. 304, p. 24-33, 2016.
dc.identifier.doi10.1016/j.bbr.2016.02.012
dc.identifier.issn0166-4328
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56027
dc.identifier.wosWOS:000372939400004
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofBehavioural Brain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAversive memoryen
dc.subjectAnxietyen
dc.subjectHippocampusen
dc.subjectMuscimolen
dc.subjectPlus-maze discriminative avoidance tasken
dc.titleHippocampal-dependent memory in the plus-maze discriminative avoidance task: The role of spatial cues and CA1 activityen
dc.typeinfo:eu-repo/semantics/article
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