Comparative study of liponucleosides in Langmuir monolayers as cell membrane models

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dc.contributor.authorMontanha, E. A.
dc.contributor.authorCaseli, L. [UNIFESP]
dc.contributor.authorKaczmarek, O.
dc.contributor.authorLiebscher, J.
dc.contributor.authorHuster, D.
dc.contributor.authorOliveira, O. N.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionHumboldt Univ
dc.contributor.institutionUniv Leipzig
dc.date.accessioned2016-01-24T14:05:58Z
dc.date.available2016-01-24T14:05:58Z
dc.date.issued2011-01-01
dc.description.abstractLiponucleosides may assist the anchoring of nucleic acid nitrogen bases into biological membranes for tailored nanobiotechnological applications. To this end precise knowledge about the biophysical and chemical details at the membrane surface is required. in this paper, we used Langmuir monolayers as simplified cell membrane models and studied the insertion of five lipidated nucleosides. These molecules varied in the type of the covalently attached lipid group, the nucleobase, and the number of hydrophobic moieties attached to the nucleoside. All five lipidated nucleosides were found to be surface-active and capable of forming stable monolayers. They could also be incorporated into dipalmitoylphosphatidylcholine (DPPC) monolayers, four of which induced expansion in the surface pressure isotherm and a decrease in the surface compression modulus of DPPC. in contrast, one nucleoside possessing three alkyl chain modifications formed very condensed monolayers and induced film condensation and an increase in the compression modulus for the DPPC monolayer, thus reflecting the importance of the ability of the nucleoside molecules to be arranged in a closely packed manner. the implications of these results lie on the possibility of tuning nucleic acid pairing by modifying structural characteristics of the liponucleosides. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ciencias Exatas & Terra, Inst Ciencias Ambientais Quim & Farmaceut, Diadema, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Fis Sao Carlos, Sao Carlos, SP, Brazil
dc.description.affiliationHumboldt Univ, Inst Chem, D-12489 Berlin, Germany
dc.description.affiliationUniv Leipzig, Inst Med Phys & Biophys, D-04107 Leipzig, Germany
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ciencias Exatas & Terra, Inst Ciencias Ambientais Quim & Farmaceut, Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipnBioNet (Brazil)
dc.description.sponsorshipFederal Ministry of Education and Research
dc.description.sponsorshipIDFederal Ministry of Education and Research: BMBF 0312027C
dc.description.sponsorshipIDFederal Ministry of Education and Research: 0312027D
dc.description.sponsorshipIDFederal Ministry of Education and Research: 0312018
dc.format.extent154-158
dc.identifierhttp://dx.doi.org/10.1016/j.bpc.2010.10.010
dc.identifier.citationBiophysical Chemistry. Amsterdam: Elsevier B.V., v. 153, n. 2-3, p. 154-158, 2011.
dc.identifier.doi10.1016/j.bpc.2010.10.010
dc.identifier.issn0301-4622
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33276
dc.identifier.wosWOS:000287294000003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBiophysical Chemistry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectLangmuir monolayersen
dc.subjectLiponucleotidesen
dc.subjectDPPCen
dc.subjectBiomembraneen
dc.titleComparative study of liponucleosides in Langmuir monolayers as cell membrane modelsen
dc.typeinfo:eu-repo/semantics/article
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