Association of high post-transplant soluble CD30 serum levels with, chronic allograft nephropathy

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dc.contributor.authorGrenzi, Patricia C. [UNIFESP]
dc.contributor.authorCampos, Erika F. [UNIFESP]
dc.contributor.authorTedesco-Silva, Helio
dc.contributor.authorFelipe, Claudia R.
dc.contributor.authorFranco, Marcello F. [UNIFESP]
dc.contributor.authorSoares, Maria Fernanda Sanches [UNIFESP]
dc.contributor.authorMedina-Pestana, Jose Osmar [UNIFESP]
dc.contributor.authorGerbase-DeLima, Maria [UNIFESP]
dc.contributor.institutionAFIP
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Rim & Hipertensao
dc.contributor.institutionUniv Fed Parana
dc.date.accessioned2016-01-24T14:34:49Z
dc.date.available2016-01-24T14:34:49Z
dc.date.issued2013-12-01
dc.description.abstractThe purpose of this study was to evaluate the association of post-transplant soluble CD30 (sCD30) levels, isolated or in combination with of anti-HLA class II antibodies and of serum creatinine levels, with kidney graft loss due to chronic allograft nephropathy (CAN), and type of lesions in graft biopsies for cause. the study comprised 511 first kidney graft recipients, transplanted at a single center, with a graft functioning for at least 2.8 years. A single blood sample was collected from each patient sCD30 levels were determined by ELISA, and HIA antibodies by Luminex assay. the minimum follow-up after testing was 93 years. High sCD30 levels, set at sCD30 >= 3.415 ng/mL, the presence of HLA class II antibodies, and serum creatinine >= 1.9 mg/dL were independently associated with CAN-graft loss (P values <0.0001, 0.05, <0.0001, respectively), and the combined hazard ratio for CAN-graft loss was 20.2. Analyses of 166 biopsies for cause showed that high sCD30 levels and creatinine were independently associated with interstitial lesions. Post-transplant sCD30 serum levels, especially in conjunction with information regarding HLA class II antibodies and serum creatinine levels, provide valuable information regarding graft outcome and could be useful for the management of kidney transplant recipients. (C) 2013 Elsevier B.V. All rights reserved.en
dc.description.affiliationAFIP, Inst Immunogenet, BR-04040031 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationHosp Rim & Hipertensao, São Paulo, Brazil
dc.description.affiliationUniv Fed Parana, BR-80060000 Curitiba, PR, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2008/56110-0
dc.format.extent34-38
dc.identifierhttp://dx.doi.org/10.1016/j.trim.2013.07.003
dc.identifier.citationTransplant Immunology. Amsterdam: Elsevier B.V., v. 29, n. 1-4, p. 34-38, 2013.
dc.identifier.doi10.1016/j.trim.2013.07.003
dc.identifier.issn0966-3274
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37047
dc.identifier.wosWOS:000329145600007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofTransplant Immunology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSoluble CD30en
dc.subjectChronic allograft nephropathyen
dc.subjectAlloantibodiesen
dc.subjectKidney transplantationen
dc.subjectPost-transplant monitoringen
dc.subjectImmunologic monitoringen
dc.titleAssociation of high post-transplant soluble CD30 serum levels with, chronic allograft nephropathyen
dc.typeinfo:eu-repo/semantics/article
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