Increase in bax expression and apoptosis are associated in Huntington's disease progression

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dc.contributor.authorTeles, A. V. F. F. [UNIFESP]
dc.contributor.authorRosenstock, T. R. [UNIFESP]
dc.contributor.authorOkuno, C. S. [UNIFESP]
dc.contributor.authorLopes, G. S. [UNIFESP]
dc.contributor.authorBertoncini, C. R. A. [UNIFESP]
dc.contributor.authorSmaili, Soraya Soubhi [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:51:28Z
dc.date.available2016-01-24T13:51:28Z
dc.date.issued2008-06-13
dc.description.abstractHuntington's disease (HD) is a hereditary dominant neurodegenerative disorder and the progression of the disease may be associated with apoptosis and altered expression of apoptotic proteins. the aim of this study was to investigate gene expression of bax and bcl-2 in tissues from R6/1 transgenic (TGN) mice of different ages (3, 6 and 9 months). the mRNA expression was investigated and related to apoptotic cells measured by TUNEL Results showed a significant and progressive increase in box levels in the cortex of TGN (from 10 to 33%) when compared to control (CT) (8 to 20%) mice with 3, 6 and 9-month-old. the increase in box was correlated with the elevation in the number of apoptotic nuclei, especially in the cortex of 6 (10%) and 9 (18%)-month-old mice. Increase in bax expression might be related to an apoptotic induction which contributes to the HD progression. (C) 2008 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pharmacol, BR-04044020 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, CEDEME, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pharmacol, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, CEDEME, BR-04044020 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent59-63
dc.identifierhttp://dx.doi.org/10.1016/j.neulet.2008.03.062
dc.identifier.citationNeuroscience Letters. Clare: Elsevier B.V., v. 438, n. 1, p. 59-63, 2008.
dc.identifier.doi10.1016/j.neulet.2008.03.062
dc.identifier.issn0304-3940
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30730
dc.identifier.wosWOS:000257152000014
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience Letters
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectbcl-2en
dc.subjectbaxen
dc.subjectmRNAen
dc.subjectapoptosisen
dc.subjectagingen
dc.subjectHuntington's diseaseen
dc.subjectneurodegenerationen
dc.subjectcell deathen
dc.titleIncrease in bax expression and apoptosis are associated in Huntington's disease progressionen
dc.typeinfo:eu-repo/semantics/article
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