Differential clinicopathological risk and prognosis of major papillary thyroid cancer variants

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dc.contributor.authorShi, Xiaoguang
dc.contributor.authorLiu, Rengyun
dc.contributor.authorBasolo, Fulvio
dc.contributor.authorGiannini, Riccardo
dc.contributor.authorShen, Xiaopei
dc.contributor.authorTeng, Di
dc.contributor.authorGuan, Haixia
dc.contributor.authorShan, Zhongyan
dc.contributor.authorTeng, Weiping
dc.contributor.authorMusholt, Thomas J.
dc.contributor.authorAl-Kuraya, Khawla
dc.contributor.authorFugazzola, Laura
dc.contributor.authorColombo, Carla
dc.contributor.authorKebebew, Electron
dc.contributor.authorJarzab, Barbara
dc.contributor.authorCzarniecka, Agnieszka
dc.contributor.authorBendlova, Bela
dc.contributor.authorSykorova, Vlasta
dc.contributor.authorSobrinho-Simoes, Manuel
dc.contributor.authorSoares, Paula
dc.contributor.authorShong, Young Kee
dc.contributor.authorKim, Tae Yong
dc.contributor.authorCheng, Sonia
dc.contributor.authorAsa, Sylvia L.
dc.contributor.authorViola, David
dc.contributor.authorElisei, Rossella
dc.contributor.authorYip, Linwah
dc.contributor.authorMian, Caterina
dc.contributor.authorVianello, Federica
dc.contributor.authorWang, Yangang
dc.contributor.authorZhao, Shihua
dc.contributor.authorOler, Gisele [UNIFESP]
dc.contributor.authorCerutti, Janete Maria [UNIFESP]
dc.contributor.authorPuxeddu, Efisio
dc.contributor.authorQu, Shen
dc.contributor.authorWei, Qing
dc.contributor.authorXu, Huixiong
dc.contributor.authorO'Neill, Christine J.
dc.contributor.authorSywak, Mark S.
dc.contributor.authorClifton-Bligh, Roderick
dc.contributor.authorLam, Alfred K.
dc.contributor.authorRiesco-Eizaguirre, Garcilaso
dc.contributor.authorSantisteban, Pilar
dc.contributor.authorYu, Hongyu
dc.contributor.authorTallini, Giovanni
dc.contributor.authorHolt, Elizabeth H.
dc.contributor.authorVasko, Vasily
dc.contributor.authorXing, Mingzhao
dc.date.accessioned2019-01-21T10:29:57Z
dc.date.available2019-01-21T10:29:57Z
dc.date.issued2016
dc.description.abstractContext: Individualized management, incorporating papillary thyroid cancer (PTC) variant-specific risk, is conceivably a useful treatment strategy for PTC, which awaits comprehensive data demonstrating differential risks of PTC variants to support. Objective: This study sought to establish the differential clinicopathological risk of major PTC variants: conventional PTC (CPTC), follicular-variant PTC (FVPTC), and tall-cell PTC (TCPTC). Methods: This was a retrospective study of clinicopathological outcomes of 6282 PTC patients (4799 females and 1483 males) from 26 centers and The Cancer Genome Atlas in 14 countries with a median age of 44 years (interquartile range, 33-56 y) and median follow-up time of 37 months (interquartile range, 15-82 mo). Results: The cohort consisted of 4702 (74.8%) patients with CPTC, 1126 (17.9%) with FVPTC, and 239 (3.8%) with TCPTC. The prevalence of high-risk parameters was significantly different among the three variants, including extrathyroidal invasion, lymph node metastasis, stages III/IV, disease recurrence, mortality, and the use (need) of radioiodine treatment (all P < .001), being highest in TCPTC, lowest in FVPTC, and intermediate in CPTC, following an order of TCPTC > CPTC >> FVPTC. Recurrence and mortality in TCPTC, CPTC, and FVPTC were 27.3 and 6.7%, 16.1 and 2.5%, and 9.1 and 0.6%, corresponding to events per 1000 person-years (95% confidence interval [CI]) of 92.47 (64.66-132.26) and 24.61 (12.31-49.21), 34.46 (30.71-38.66), and 5.87 (4.37-7.88), and 24.73 (18.34-33.35) and 1.68 (0.54-5.21), respectively. Mortality hazard ratios of CPTC and TCPTC over FVPTC were 3.44 (95% CI, 1.07-11.11) and 14.96 (95% CI, 3.93-56.89), respectively. Kaplan-Meier survival analyses showed the best prognosis in FVPTC, worst in TCPTC, and intermediate in CPTC in disease recurrence-free probability and disease-specific patient survival. This was particularly the case in patients at least 45 years old. Conclusion: This large multicenter study demonstrates differential prognostic risks of the three major PTC variants and establishes a unique risk order of TCPTC > CPTC >> FVPTC, providing important clinical implications for specific variant-based management of PTC.en
dc.description.affiliationLaboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287
dc.description.affiliationDepartment of Surgery, Division of Pathology, 56126 Pisa, Italy
dc.description.affiliationThe Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases, Department of Endocrinology and Metabolism, The First Hospital of China Medical University, Shenyang, Liaoning Province 110001, China
dc.description.affiliationEndocrine Surgery, University Medical Center, Johannes Gutenberg University Mainz, 55101 Mainz, Germany
dc.description.affiliationHuman Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh 12713, Kingdom of Saudi Arabia
dc.description.affiliationFondazione Instituto di Ricovero e Cura a Carattere Scientifico Ca’ Granda Policlinico, Milan, and Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan Italy
dc.description.affiliationEndocrine Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
dc.description.affiliationMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, 44-101 Gliwice, Poland
dc.description.affiliationDepartment of Molecular Endocrinology, Institute of Endocrinology, Prague 11694, Czech Republic
dc.description.affiliationInstitute of Molecular Pathology and Immunology, University of Porto (Ipatimup) and Medical Faculty of the University of Porto, 4200-319 Porto, Portugal
dc.description.affiliationCollege of Medicine, University of Ulsan College of Medicine, Seoul, South Korea
dc.description.affiliationDepartment of Pathology, University Health Network, Toronto, ON M5G 2C4 Canada
dc.description.affiliationEndocrine Unit, Department of Clinical and Experimental Medicine, World Health Organization, Collaborating Center for the Study and Treatment of Thyroid Diseases and Other Endocrine and Metabolic Disorders, University of Pisa, 56124 Pisa, Italy
dc.description.affiliationUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213
dc.description.affiliationDepartment of Medicine, Endocrinology Unit, University of Padua, Padua 35128, Italy
dc.description.affiliationVeneto Institute of Oncology, IRCCS, Padua 35128, Italy
dc.description.affiliationDepartment of Endocrinology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China
dc.description.affiliationGenetic Bases of Thyroid Tumor Laboratory, Division of Genetics, Federal University of São Paulo, São Paulo 04039-032, Brazil
dc.description.affiliationDepartment of Internal Medicine, University of Perugia, 06100 Perugia, Italy
dc.description.affiliationDepartment of Endocrinology, Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Thyroid Institute, Tongji University School of Medicine, Shanghai, 200072, China
dc.description.affiliationEndocrine Surgical Unit , The University of Sydney, Sydney 2052, Australia
dc.description.affiliationCancer Molecular Pathology of Menzies Health Institute Queensland, Griffith University–Gold Coast, Southport 4215, Australia
dc.description.affiliationHospital La Paz, Health Research Institute, and Hospital Universitario de Móstoles, and Biomedical Research Institute, “Alberto Sols,” Spanish Council of Research Consejo Superior de Investigaciones Científicas, and Autonomous University of Madrid, Madrid, 28029 Madrid, Spain
dc.description.affiliationDepartment of Pathology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
dc.description.affiliationDepartment of Medicine, Anatomic Pathology Unit, Ospedale Bellaria, University of Bologna, 40139 Bologna, Italy
dc.description.affiliationEndocrine Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520
dc.description.affiliationDepartment of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814
dc.description.affiliationUnifespGenetic Bases of Thyroid Tumor Laboratory, Division of Genetics, Federal University of São Paulo, São Paulo 04039-032, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipUS National Institutes of Health (NIH) [RO1CA113507, R01CA189224]
dc.description.sponsorshipNational Science Centre Poland (Poland) [N403 194340, N N401 612440, 267398]
dc.description.sponsorshipQueensland Government (Australia)
dc.description.sponsorshipGriffith Health Institute (Australia)
dc.description.sponsorshipFondazione Cassa di Risparmio di Perugia (Italy)
dc.description.sponsorshipAssociazione Italiana per la Ricerca sul Cancro (Italy) [IG 9338]
dc.description.sponsorshipBeadle Family Foundation (San Antonio, TX)
dc.description.sponsorshipNew South Wales Cancer Institute (Australia)
dc.description.sponsorshipCancer Council of New South Wales (Australia)
dc.description.sponsorshipItalian Government-Ministero della Salute (Italy) [RF-2011-02350857]
dc.description.sponsorshipMinisterodella Istruzione Universitaria e Ricerca Scientifica (Italy)
dc.description.sponsorshipAssociazioneItaliana per la Ricerca sul Cancro (Italy)
dc.description.sponsorshipIstituto Toscano Tumori (Italy)
dc.description.sponsorshipMinistero della Salute (Italy)
dc.description.sponsorshipKorean Foundation for Cancer Research (South Korea) [CB-2011-03-02]
dc.description.sponsorshipSao Paulo State Research Foundation (FAPESP) [2012/02902-9, 2013/03867-5]
dc.description.sponsorshipAIRC (Italy) [IG 10316]
dc.description.sponsorshipShanghai Hospital Development Center (China) [SHDC 12014229]
dc.description.sponsorshipPrograma Operacional Regional do Norte (ON.2-O Novo Norte), under the Quadro de Referencia Estrategico Nacional
dc.description.sponsorshipFundo Europeu de Desenvolvimento Regional
dc.description.sponsorship[RD12/0036/0030 FIS-ISCIII]
dc.description.sponsorship[S2011/BMD-2328 TIRONET]
dc.description.sponsorship[SAF2013-44709-R]
dc.description.sponsorship[IGA MH CR NT 13901-4]
dc.description.sponsorship[NIH/NIA 5R03AG042334-02]
dc.description.sponsorshipIDNIH: RO1CA113507
dc.description.sponsorshipIDNIH: R01CA189224
dc.description.sponsorshipIDNational Science Centre Poland: N403 194340
dc.description.sponsorshipIDNational Science Centre Poland: N N401 612440
dc.description.sponsorshipIDMilestone: 267398
dc.description.sponsorshipIDQueensland Government Smart State Fellowship and Griffith Health Institute: RD12/0036/0030 FIS-ISCIII
dc.description.sponsorshipIDQueensland Government Smart State Fellowship and Griffith Health Institute: S2011/BMD-2328 TIRONET
dc.description.sponsorshipIDQueensland Government Smart State Fellowship and Griffith Health Institute: SAF2013-44709-R
dc.description.sponsorshipIDFondazione Cassa di Risparmio di Perugia and Associazione Italiana per la Ricerca sul Cancro: IG 9338
dc.description.sponsorshipIDIGA MH CR NT: 13901-4
dc.description.sponsorshipIDItalian Government-Ministero della Salute:RF-2011-02350857
dc.description.sponsorshipIDNIH/NIA: 5R03AG042334-02
dc.description.sponsorshipIDKorean Foundation for Cancer Research: CB-2011-03-02
dc.description.sponsorshipIDFAPESP: 2012/02902-9
dc.description.sponsorshipIDFAPESP: 2013/03867-5
dc.description.sponsorshipIDAIRC: IG 10316
dc.description.sponsorshipIDShanghai Hospital Development Center: SHDC 12014229
dc.format.extent263-273
dc.identifierhttps://doi.org/10.1210/jc.2015-2917
dc.identifier.citationJournal Of Clinical Endocrinology & Metabolism. Cary, v. 101, n. 1, p. 263-273, 2016.
dc.identifier.doi10.1210/jc.2015-2917
dc.identifier.issn0021-972X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49497
dc.identifier.wosWOS:000377212700034
dc.language.isoeng
dc.publisherOxford univ press inc
dc.relation.ispartofJournal Of Clinical Endocrinology & Metabolism
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBraf V600e Mutationen
dc.subjectTall-Cell Varianten
dc.subjectNeedle-Aspiration Biopsyen
dc.subjectTerm-Follow-Upen
dc.subjectFollicular Varianten
dc.subjectBraf(V600e) Mutationen
dc.subjectSurgical-Treatmenten
dc.subjectClinical-Featuresen
dc.subjectCarcinomaen
dc.subjectAssociationen
dc.titleDifferential clinicopathological risk and prognosis of major papillary thyroid cancer variantsen
dc.typeinfo:eu-repo/semantics/article
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