Pluripotent stem cell transcription factors during human odontogenesis

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dc.contributor.authorCunha, Juliana Malta da [UNIFESP]
dc.contributor.authorCosta-Neves, Adriana da
dc.contributor.authorKerkis, Irina
dc.contributor.authorPereira da Silva, Marcelo Cavenaghi [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Butantan
dc.date.accessioned2016-01-24T14:34:20Z
dc.date.available2016-01-24T14:34:20Z
dc.date.issued2013-09-01
dc.description.abstractStem cells are capable of generating various cell lines and can be obtained from adult or embryonic tissues for clinical therapies. Stem cells from deciduous dental pulp are among those that are easily obtainable from adult tissues and have been widely studied because of their ability to differentiate into a variety of cell lines in the presence of various chemical mediators. We have analyze the expression of several proteins related to the differentiation and proliferative potential of cell populations that compose the tooth germ of human fetuses. We evaluate 20 human fetuses of both genders. After being paraffin-embedded, cap and bell stages of tooth germ development were subjected to immunohistochemistry for the following markers: Oct-4, Nanog, Stat-3 and Sox-2. the studied antibodies showed nuclear or cytoplasmic immunnostaining within various anatomical structures and with various degrees of expression, indicating the action of these proteins during tooth development. We conclude that the interrelationship between these transcription factors is complex and associated with self-renewal and cell differentiation. Our results suggest that the expression of Oct-4, Nanog, Sox-2 and Stat-3 are related to differentiation in ameloblasts and odontoblasts.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morfol & Genet, São Paulo, Brazil
dc.description.affiliationInst Butantan, Lab Biol Celular, São Paulo, Brazil
dc.description.affiliationInst Butantan, Genet Lab, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morfol & Genet, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2010/08085-7
dc.format.extent435-441
dc.identifierhttp://dx.doi.org/10.1007/s00441-013-1658-y
dc.identifier.citationCell and Tissue Research. New York: Springer, v. 353, n. 3, p. 435-441, 2013.
dc.identifier.doi10.1007/s00441-013-1658-y
dc.identifier.issn0302-766X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36694
dc.identifier.wosWOS:000323620800008
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofCell and Tissue Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectStem cellsen
dc.subjectTranscription factorsen
dc.subjectOdontogenesisen
dc.subjectDevelopmental biologyen
dc.subjectTooth developmenten
dc.subjectHumanen
dc.titlePluripotent stem cell transcription factors during human odontogenesisen
dc.typeinfo:eu-repo/semantics/article
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