Autonomic and renal alterations in the offspring of sleep-restricted mothers during late pregnancy

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dc.contributor.authorRaimundo, Joyce Regina Santos [UNIFESP]
dc.contributor.authorBergamaschi, Cassia Toledo [UNIFESP]
dc.contributor.authorPalma, Beatriz Duarte [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorGomes, Guiomar Nascimento [UNIFESP]
dc.contributor.authorCampos, Ruy Ribeiro [UNIFESP]
dc.date.accessioned2019-01-21T10:29:49Z
dc.date.available2019-01-21T10:29:49Z
dc.date.issued2016
dc.description.abstractOBJECTIVES: Considering that changes in the maternal environment may result in changes in progeny, the aim of this study was to investigate the influence of sleep restriction during the last week of pregnancy on renal function and autonomic responses in male descendants at an adult age. METHODS: After confirmation of pregnancy, female Wistar rats were randomly assigned to either a control or a sleep restriction group. The sleep-restricted rats were subjected to sleep restriction using the multiple platforms method for over 20 hours per day between the 14 th and 20 th day of pregnancy. After delivery, the litters were limited to 6 offspring that were designated as offspring from control and offspring from sleep-restricted mothers. Indirect measurements of systolic blood pressure (BPi), renal plasma flow, glomerular filtration rate, glomerular area and number of glomeruli per field were evaluated at three months of age. Direct measurements of cardiovascular function (heart rate and mean arterial pressure), cardiac sympathetic tone, cardiac parasympathetic tone, and baroreflex sensitivity were evaluated at four months of age. RESULTS: The sleep-restricted offspring presented increases in BPi, glomerular filtration rate and glomerular area compared with the control offspring. The sleep-restricted offspring also showed higher basal heart rate, increased mean arterial pressure, increased sympathetic cardiac tone, decreased parasympathetic cardiac tone and reduced baroreflex sensitivity. CONCLUSIONS: Our data suggest that reductions in sleep during the last week of pregnancy lead to alterations in cardiovascular autonomic regulation and renal morpho-functional changes in offspring, triggering increases in blood pressure.en
dc.description.affiliationEscola Paulista de Medicina - UNIFESP, Departamento de Fisiologia, São Paulo/SP, Brazil
dc.description.affiliationEscola Paulista de Medicina - UNIFESP, Departamento de Psicobiologia, São Paulo/SP, Brazil
dc.description.affiliationCentro Universitário São Camilo, São Paulo/SP, Brazil
dc.description.affiliationUnifespEscola Paulista de Medicina - UNIFESP, Departamento de Fisiologia, São Paulo/SP, Brazil
dc.description.affiliationUnifespEscola Paulista de Medicina - UNIFESP, Departamento de Psicobiologia, São Paulo/SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 2013-23622-7
dc.format.extent521-527
dc.identifierhttps://dx.doi.org/10.6061/clinics/2016(09)07
dc.identifier.citationClinics. Sao paulo, v. 71, n. 9, p. 521-527, 2016.
dc.identifier.doi10.6061/clinics/2016(09)07
dc.identifier.fileS1807-59322016000900521.pdf
dc.identifier.issn1807-5932
dc.identifier.scieloS1807-59322016000900521
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/49411
dc.identifier.wosWOS:000382872800007
dc.language.isoeng
dc.publisherAtha Comunicacao & Editora
dc.relation.ispartofClinics
dc.rightsAcesso aberto
dc.subjectPrenatal Exposure Delayed Effectsen
dc.subjectHypertensionen
dc.subjectKidney Diseaseen
dc.subjectSleep RestrictionBlood-Pressureen
dc.subjectAngiotensin-Iien
dc.subjectHeart-Rateen
dc.subjectAntenatal Betamethasoneen
dc.subjectCardiovascular-Diseaseen
dc.subjectEssential-Hypertensionen
dc.subjectArterial-Pressureen
dc.subjectDeprivationen
dc.subjectRatsen
dc.subjectStressen
dc.titleAutonomic and renal alterations in the offspring of sleep-restricted mothers during late pregnancyen
dc.typeArtigo
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