H-1-NMR, H-1-NMR T-2-edited, and 2D-NMR in bipolar disorder metabolic profiling

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dc.citation.volume5]
dc.contributor.authorSethi, Sumit [UNIFESP]
dc.contributor.authorPedrini, Mariana [UNIFESP]
dc.contributor.authorRizzo, Lucas B. [UNIFESP]
dc.contributor.authorZeni-Graiff, Maiara [UNIFESP]
dc.contributor.authorDal Mas, Caroline [UNIFESP]
dc.contributor.authorCassinelli, Ana Claudia
dc.contributor.authorNoto, Mariane N. [UNIFESP]
dc.contributor.authorAsevedo, Elson [UNIFESP]
dc.contributor.authorCordeiro, Quirino
dc.contributor.authorPontes, Joao G. M.
dc.contributor.authorBrasil, Antonio J. M.
dc.contributor.authorLacerda, Acioly [UNIFESP]
dc.contributor.authorHayashi, Mirian A. F. [UNIFESP]
dc.contributor.authorPoppi, Ronei
dc.contributor.authorTasic, Ljubica
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.coverageHeidelberg
dc.date.accessioned2020-06-26T16:30:37Z
dc.date.available2020-06-26T16:30:37Z
dc.date.issued2017
dc.description.abstractBackground: The objective of this study was to identify molecular alterations in the human blood serum related to bipolar disorder, using nuclear magnetic resonance (NMR) spectroscopy and chemometrics. Methods: Metabolomic profiling, employing H-1-NMR, H-1-NMR -T-2-edited, and 2D-NMR spectroscopy and chemometrics of human blood serum samples from patients with bipolar disorder (n = 26) compared with healthy volunteers (n = 50) was performed. Results: The investigated groups presented distinct metabolic profiles, in which the main differential metabolites found in the serum sample of bipolar disorder patients compared with those from controls were lipids, lipid metabolism-related molecules (choline, myo-inositol), and some amino acids (N-acetyl-L-phenyl alanine, N-acetyl-L-aspartyl-L-glutamic acid, L-glutamine). In addition, amygdalin, alpha-ketoglutaric acid, and lipoamide, among other compounds, were also present or were significantly altered in the serum of bipolar disorder patients. The data presented herein suggest that some of these metabolites differentially distributed between the groups studied may be directly related to the bipolar disorder pathophysiology. Conclusions: The strategy employed here showed significant potential for exploring pathophysiological features and molecular pathways involved in bipolar disorder. Thus, our findings may contribute to pave the way for future studies aiming at identifying important potential biomarkers for bipolar disorder diagnosis or progression follow-up.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Psychiat, Rua Borges Lagoa 570, BR-04038020 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Pharmacol, Rua Tres Maio 100, BR-04044020 Sao Paulo, Brazil
dc.description.affiliationISCMSP, Dept Psychiat, Rua Major Maragliano 287, BR-04017030 Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas UNICAMP, Lab Quim Biol, Dept Organ Chem, Inst Chem, Caixa Postal 6154, BR-13083970 Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas UNICAMP, Dept Analyt Chem, Inst Chem, Caixa Postal 6154, BR-13083970 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Psychiat, Rua Borges Lagoa 570, BR-04038020 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Pharmacol, Rua Tres Maio 100, BR-04044020 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brasilia, Brazil)
dc.description.sponsorshipFAPESP
dc.description.sponsorshipIDCNPq
dc.description.sponsorshipIDFAPESP: 2014/18938-8
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1186/s40345-017-0088-2]
dc.identifier.citationInternational Journal Of Bipolar Disorders. Heidelberg, v. 5, p. -, 2017.
dc.identifier.doi10.1186/s40345-017-0088-2
dc.identifier.fileWOS000403186100001.pdf
dc.identifier.issn2194-7511
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53670
dc.identifier.wosWOS:000403186100001
dc.language.isoeng
dc.publisherSpringer Heidelberg
dc.relation.ispartofInternational Journal Of Bipolar Disorders
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectH-1-NMRen
dc.subjectBiomarkersen
dc.subjectBipolar disorderen
dc.subjectMetabolic profilingen
dc.subjectChemometricsen
dc.subject2D NMRen
dc.titleH-1-NMR, H-1-NMR T-2-edited, and 2D-NMR in bipolar disorder metabolic profilingen
dc.typeinfo:eu-repo/semantics/article
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