Effects of preoperative irradiation using fractioned electron beam on the healing process of colocolonic anastomosis in rats undergoing early and late surgical intervention

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dc.contributor.authorSimões Neto, Joaquim [UNIFESP]
dc.contributor.authorReis Neto, José Alfredo Dos
dc.contributor.authorMatos, Delcio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionPUCCAMP Department of Surgery
dc.contributor.institutionMetropolitan University of Santos
dc.date.accessioned2015-06-14T13:45:14Z
dc.date.available2015-06-14T13:45:14Z
dc.date.issued2013-01-01
dc.description.abstractPURPOSE: To investigate the effects of preoperative fractioned irradiation using an electron beam on the healing process of colocolonic anastomoses in rats that underwent early and late surgical intervention. METHODS: Thirty Wistar rats, distributed as follows: group A (surgery only), group B (fractionated irradiation for 30 days (if), surgery seven days after the end of it), group C (if for 30 days, and surgery after 30 days of termination). On the seventh postoperative day the anastomotic segment analysis was taken, using tension tests, histology and collagen deposition evaluation by computerized analysis. RESULTS: Regarding the tension resistance of the anastomosis, there were no statistical differences (p=0.42). However, a significant increase in cells number in the inflammatory infiltrate in the group with a longer interval between surgery and pre op radiation (p<0.05). The collagen concentration had no significant variance. CONCLUSION: The irradiation in divided doses increased local inflammatory cellularity when the surgery was performed later. This result did not affect the increase of complications, nor on the local concentration of collagen, achieving similar clinical outcomes.en
dc.description.affiliationUNIFESP Postgraduate Program in Surgical Gastroenterology
dc.description.affiliationPUCCAMP Department of Surgery
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Department of Surgery Division of Surgical Gastroenterology
dc.description.affiliationMetropolitan University of Santos
dc.description.affiliationUnifespUNIFESP, Postgraduate Program in Surgical Gastroenterology
dc.description.affiliationUnifespUNIFESP, Department of Surgery Division of Surgical Gastroenterology
dc.description.sourceSciELO
dc.format.extent72-77
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502013000100012
dc.identifier.citationActa Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 1, p. 72-77, 2013.
dc.identifier.doi10.1590/S0102-86502013000100012
dc.identifier.fileS0102-86502013000100012.pdf
dc.identifier.issn0102-8650
dc.identifier.scieloS0102-86502013000100012
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/7582
dc.identifier.wosWOS:000313866600011
dc.language.isoeng
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDose Fractionationen
dc.subjectAnastomosis, Surgicalen
dc.subjectColonen
dc.subjectWound Healingen
dc.subjectSurgical Procedures, Operativeen
dc.subjectRatsen
dc.titleEffects of preoperative irradiation using fractioned electron beam on the healing process of colocolonic anastomosis in rats undergoing early and late surgical interventionen
dc.typeinfo:eu-repo/semantics/article
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