Effects of morphine or naloxone on cocaine-induced genital reflexes in paradoxical sleep-deprived rats

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dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorFrussa-Filho, Roberto [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:37:28Z
dc.date.available2016-01-24T12:37:28Z
dc.date.issued2004-11-01
dc.description.abstractThe involvement of opioidergic neurotransmission in the modulation of genital reflexes induced by paradoxical sleep deprivation (PSD) and cocaine in rats was the aim of the present study. Morphine (0, 1, 5 and 10 mg/kg) and naloxone (0, 0.3, 3 and 30 mg/kg) were administered prior to saline or cocaine to rats that had been deprived of sleep and the incidence of penile erections (PE) and ejaculations (EJ) was measured. PSD alone induced PE in 50% and EJ in 20% of the rats, but these behaviors were not influenced by morphine or naloxone. Cocaine potentiated the incidence of genital reflexes in PSD rats to 90% (PE) and 70% (EJ). Morphine and not naloxone significantly reduced the percentage of rats displaying this response at the highest doses. Morphine also significantly reduced PE and EJ frequencies at 10 mg/kg. Furthermore, this inhibitory effect of morphine on genital reflexes was prevented by the prior injection of naloxone. Although a number of factors are involved in such a complex phenomenon as PE and EJ, our data show that activation of the opioidergic systems by the agonist morphine reduces genital reflexes-induced by cocaine in PSD males while the antagonist, naloxone, did not have any significant effect. the findings suggest that the stimulating effects of cocaine in potentiating genital reflexes in PSD rats can be unidirectionally modified by opioidergic systems. (C) 2004 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pharmacol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pharmacol, BR-04024002 São Paulo, Brazil
dc.description.provenanceMade available in DSpace on 2016-01-24T12:37:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2004-11-01en
dc.description.sourceWeb of Science
dc.format.extent515-521
dc.identifierhttps://dx.doi.org/10.1016/j.pbb.2004.09.003
dc.identifier.citationPharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 79, n. 3, p. 515-521, 2004.
dc.identifier.doi10.1016/j.pbb.2004.09.003
dc.identifier.issn0091-3057
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/28010
dc.identifier.wosWOS:000225871200013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.rightsAcesso restrito
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSleep deprivationen
dc.subjectGenital reflexesen
dc.subjectMorphineen
dc.subjectNaloxoneen
dc.subjectOpioiden
dc.subjectCocaineen
dc.subjectSexual behavioren
dc.subjectRaten
dc.titleEffects of morphine or naloxone on cocaine-induced genital reflexes in paradoxical sleep-deprived ratsen
dc.typeArtigo
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