Gestational tissue inflammatory biomarkers at term labor: Asystematic review of literature

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dc.citation.issue2
dc.citation.volume79
dc.contributor.authorHadley, Emily E.
dc.contributor.authorRichardson, Lauren S.
dc.contributor.authorTorloni, Maria R. [UNIFESP]
dc.contributor.authorMenon, Ramkumar
dc.coverageHoboken
dc.date.accessioned2020-07-08T13:09:49Z
dc.date.available2020-07-08T13:09:49Z
dc.date.issued2018
dc.description.abstractParturition at term is characterized by inflammatory overload in both feto-maternal tissues. Despite the large number of individual studies on changes in inflammatory biomarkers linked to labor, a comprehensive profile of them in each of the uterine compartments is not available to better understand their mechanistic contributions to labor. This systematic review investigated the pro- and anti-inflammatory biomarkers reported in intra-uterine tissues (amnion, chorion, decidua, placenta, and myometrium) at term labor. We conducted a systematic review of studies on pro- and anti-inflammatory biomarkers (mRNA and/or protein) reported in feto-maternal tissues during normal human term labor, published in English (1980-2016), in 3 electronic data bases. From a total of 3712 citations, 172 were included for final review. Each tissue expresses a unique set of biomarkers at the time of term labor, but there is significant overlap between tissues. All tissues had IL-6, IL-8, IL-1, COX-2, PGE-2, TNF-, and hCAP18 in common at term labor. Common and unique inflammatory biomarkers are expressed in various feto-maternal compartments at term labor. Increase in pro-inflammatory markers in all gestational tissue signifies their harmonious functional role in promoting labor. Anti-inflammatory markers at term labor are hardly reported.en
dc.description.affiliationUniv Texas Med Branch, Dept Obstet & Gynecol, Div Maternal Fetal Med & Perinatal Res, Galveston, TX 77555 USA
dc.description.affiliationUniv Fed Sao Paulo, Dept Obstet & Gynecol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Obstet & Gynecol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNICHD
dc.description.sponsorshipIDNICHD: 1R03HD086354-01
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1111/aji.12776
dc.identifier.citationAmerican Journal Of Reproductive Immunology. Hoboken, v. 79, n. 2, p. -, 2018.
dc.identifier.doi10.1111/aji.12776
dc.identifier.issn1046-7408
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54229
dc.identifier.wosWOS:000423176200001
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofAmerican Journal Of Reproductive Immunology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectdeciduaen
dc.subjectfetal membranesen
dc.subjectinflammationen
dc.subjectmyometriumen
dc.subjectplacentaen
dc.subjectsystematic reviewen
dc.titleGestational tissue inflammatory biomarkers at term labor: Asystematic review of literatureen
dc.typeinfo:eu-repo/semantics/article
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