Serum copeptin in children exposed to maltreatment

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dc.citation.issue10
dc.citation.volume70
dc.contributor.authorCoelho, Roberta
dc.contributor.authorLevandowski, Mateus L.
dc.contributor.authorMansur, Rodrigo B.
dc.contributor.authorCunha, Graccielle Rodrigues da [UNIFESP]
dc.contributor.authorAsevedo, Elson [UNIFESP]
dc.contributor.authorZugman, Andre [UNIFESP]
dc.contributor.authorSalum, Giovanni A.
dc.contributor.authorGadelha, Ary [UNIFESP]
dc.contributor.authorPan, Pedro Mario [UNIFESP]
dc.contributor.authorRizzo, Lucas Bortolotto [UNIFESP]
dc.contributor.authorManfro, Gisele
dc.contributor.authorMari, Jair de Jesus [UNIFESP]
dc.contributor.authorRohde, Luis A.
dc.contributor.authorMiguel, Euripedes C.
dc.contributor.authorBressan, Rodrigo Affonseca [UNIFESP]
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.contributor.authorGrassi-Oliveira, Rodrigo
dc.coverageHoboken
dc.date.accessioned2020-07-31T12:47:41Z
dc.date.available2020-07-31T12:47:41Z
dc.date.issued2016
dc.description.abstractAimChildhood maltreatment (CM) has been related to a persistent reprograming of stress-response. Copeptin is a marker of hypothalamic-pituitary-adrenal axis activationen
dc.description.abstracthowever, few studies have examined copeptin levels in children exposed to CM. The aim of this study was to compare serum copeptin levels in children reporting child abuse and/or neglect and children with no history of CM. MethodsThis study included 65 children with a positive history of moderate to severe CM, as reported by themselves and their parent(s) during a clinical interview, and 71 children with no history of CM as a comparison group. CM was considered moderate to severe based on the child-reported frequency of being exposed to events related to sexual abuse, physical abuse, emotional abuse, emotional neglect, and/or physical neglect. Child psychopathology symptoms were assessed using the Child Behavior Checklist (CBCL). We measured serum copeptin concentration using enzyme-linked immunosorbent assay. ResultsChildren exposed to CM exhibited higher levels of serum copeptin compared to children without CM when controlling for sex, age, and psychiatric morbidity. The CBCL total score, including internalizing and externalizing symptoms, was higher in children with CM. We found no correlation between copeptin and CBCL scores for internalizing symptoms and externalizing symptoms. Conclusion CM is associated with copeptin serum levels independently of age, sex, and symptom severity. Copeptin is a promising new biomarker for children with a history of abuse and/or neglect.en
dc.description.affiliationPontifical Catholic Univ Rio Grande Sul PUCRS, DCNL, Ave Ipiranga 6681,Predio 11,Sala 928 Partenon, BR-90619900 Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Dept Psychiat, Porto Alegre, RS, Brazil
dc.description.affiliationCNPq, Natl Inst Dev Psychiat Children & Adolescents, Sao Paulo, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Interdisciplinary Lab Clin Neurosci LINC, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Psychiat IPq, Sao Paulo, Brazil
dc.description.affiliationUniv Toronto, Univ Hlth Network, MDPU, Toronto, ON, Canada
dc.description.affiliationUnifespDepartment of Psychiatry, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil
dc.description.affiliationUnifespInterdisciplinary Laboratory of Clinical Neurosciences (LINC), Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institute of Developmental Psychiatry for Children and Adolescents, a science and technology institute
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDCNPq: 573974/2008-0
dc.description.sponsorshipIDCNPq: 305141/2011-2
dc.description.sponsorshipIDCNPq: 476468/ 2012-4
dc.description.sponsorshipIDFAPESP: 2008/57896-8
dc.format.extent434-441
dc.identifierhttp://dx.doi.org/10.1111/pcn.12412
dc.identifier.citationPsychiatry And Clinical Neurosciences. Hoboken, v. 70, n. 10, p. 434-441, 2016.
dc.identifier.doi10.1111/pcn.12412
dc.identifier.issn1323-1316
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56999
dc.identifier.wosWOS:000385563800003
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofPsychiatry And Clinical Neurosciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectchild abuseen
dc.subjectchild psychopathologyen
dc.subjectcopeptinen
dc.subjecthypothalamic-pituitary-adrenal axisen
dc.subjectstressen
dc.titleSerum copeptin in children exposed to maltreatmenten
dc.typeinfo:eu-repo/semantics/article
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