Whole blood hypoxia-related gene expression reveals novel pathways to obstructive sleep apnea in humans

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dc.contributor.authorPerry, Juliana C. [UNIFESP]
dc.contributor.authorGuindalini, Camila [UNIFESP]
dc.contributor.authorBittencourt, Lia [UNIFESP]
dc.contributor.authorGarbuio, Silvério Aparecido [UNIFESP]
dc.contributor.authorMazzotti, Diego R. [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:34:49Z
dc.date.available2016-01-24T14:34:49Z
dc.date.issued2013-12-01
dc.description.abstractIn this study, our goal was to identify the key genes that are associated with obstructive sleep apnea (OSA). Thirty-five volunteers underwent full in-lab polysomnography and, according to the sleep apnea hypopnea index (AHI), were classified into control, mild-to-moderate OSA and severe OSA groups. Severe OSA patients were assigned to participate in a continuous positive airway pressure (CPAP) protocol for 6 months. Blood was collected and the expression of 84 genes analyzed using the RT2 Profiler (TM) PCR array. Mild-to-moderate OSA patients demonstrated down-regulation of 2 genes associated with induction of apoptosis, while a total of 13 genes were identified in severe OSA patients. After controlling for body mass index, PRPF40A and PLOD3 gene expressions were strongly and independently associated with AHI scores. This research protocol highlights a number of molecular targets that might help the development of novel therapeutic strategies. (C) 2013 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDCNPq: 558924/2008-5
dc.description.sponsorshipIDFAPESP: 98/14303-3
dc.format.extent649-654
dc.identifierhttp://dx.doi.org/10.1016/j.resp.2013.08.012
dc.identifier.citationRespiratory Physiology & Neurobiology. Amsterdam: Elsevier B.V., v. 189, n. 3, p. 649-654, 2013.
dc.identifier.doi10.1016/j.resp.2013.08.012
dc.identifier.issn1569-9048
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37046
dc.identifier.wosWOS:000328094400026
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofRespiratory Physiology & Neurobiology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectHypoxiaen
dc.subjectObstructive sleep apneaen
dc.subjectGene expressionen
dc.subjectCPAPen
dc.subjectSleepen
dc.titleWhole blood hypoxia-related gene expression reveals novel pathways to obstructive sleep apnea in humansen
dc.typeinfo:eu-repo/semantics/article
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