Differential neuroprotection by A(1) receptor activation and A(2A) receptor inhibition following pilocarpine-induced status epilepticus

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dc.contributor.authorRosim, Fernanda Elisa [UNIFESP]
dc.contributor.authorPersike, Daniele Suzete [UNIFESP]
dc.contributor.authorNehlig, Astrid
dc.contributor.authorAmorim, Rebeca Padrão [UNIFESP]
dc.contributor.authorOliveira, Daniela Mara de
dc.contributor.authorFernandes, Maria Jose da Silva [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionINSERM
dc.contributor.institutionUniversidade de Brasília (UnB)
dc.date.accessioned2016-01-24T14:17:14Z
dc.date.available2016-01-24T14:17:14Z
dc.date.issued2011-10-01
dc.description.abstractAiming at a better understanding of the role of A(2A) in temporal lobe epilepsy (TLE), we characterized the effects of the A(2A) antagonist SCH58261 (7-(2-phenylethyl)-5-amino-2(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c] pyrimidine) on seizures and neuroprotection in the pilocarpine model. the effects of SCH58261 were further analyzed in combination with the A(1) agonist R-Pia (R(-)-N-6-(2)-phenylisopropyl adenosine). Eight groups were studied: pilocarpine (Pilo), SCH + Pilo, R-Pia + Pilo, R-Pia + SCH + Pilo, Saline, SCH + Saline, R-Pia + Saline, and R-Pia + SCH + Saline. the administration of SCH58261, R-Pia, and R-Pia + SCH58261 prior to pilocarpine increased the latency to SE, and decreased either the incidence of or rate of mortality from SE compared with controls. Administration of R-Pia and R-Pia + SCH58261 prior to pilocarpine reduced the number of Fluoro-Jade B-stained cells in the hippocampus and piriform cortex when compared with control. This study showed that pretreatment with R-Pia and SCH58261 reduces seizure occurrence, although only R-Pia has neuroprotective properties. Further studies are needed to clarify the neuroprotective role of A(2A) in TLE. (C) 2011 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurocirurgia, BR-04039032 São Paulo, Brazil
dc.description.affiliationINSERM, U666, Fac Med, Strasbourg, France
dc.description.affiliationUniv Brasilia, Dept Genet & Morfol, Inst Ciencias Biol, Brasilia, DF, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurocirurgia, BR-04039032 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent207-213
dc.identifierhttp://dx.doi.org/10.1016/j.yebeh.2011.07.004
dc.identifier.citationEpilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 22, n. 2, p. 207-213, 2011.
dc.identifier.doi10.1016/j.yebeh.2011.07.004
dc.identifier.fileWOS000295706800010.pdf
dc.identifier.issn1525-5050
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34069
dc.identifier.wosWOS:000295706800010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEpilepsy & Behavior
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectAdenosineen
dc.subjectA(2A) receptoren
dc.subjectSCH58261en
dc.subjectA(1) receptoren
dc.subjectNeuroprotectionen
dc.subjectPilocarpineen
dc.subjectStatus epilepticusen
dc.titleDifferential neuroprotection by A(1) receptor activation and A(2A) receptor inhibition following pilocarpine-induced status epilepticusen
dc.typeinfo:eu-repo/semantics/article
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