Asymmetric Macular Structural Damage Is Associated With Relative Afferent Pupillary Defects in Patients With Glaucoma

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dc.citation.issue4
dc.citation.volume57
dc.contributor.authorGracitelli, Carolina Pelegrini Barbosa [UNIFESP]
dc.contributor.authorTatham, Andrew J.
dc.contributor.authorZangwill, Linda M.
dc.contributor.authorWeinreb, Robert N.
dc.contributor.authorAbe, Ricardo Y.
dc.contributor.authorDiniz-Filho, Alberto
dc.contributor.authorParanhos Junior, Augusto [UNIFESP]
dc.contributor.authorBaig, Saif
dc.contributor.authorMedeiros, Felipe A.
dc.coverageRockville
dc.date.accessioned2020-07-22T13:23:13Z
dc.date.available2020-07-22T13:23:13Z
dc.date.issued2016
dc.description.abstractPURPOSE. We examined the relationship between relative afferent pupillary defects (RAPDs) and macular structural damage measured by macular thickness and macular ganglion cell-inner plexiform layer (mGCIPL) thickness in patients with glaucoma. METHODS. A cross-sectional study was done of 106 glaucoma patients and 85 healthy individuals from the Diagnostic Innovations in Glaucoma Study. All subjects underwent standard automated perimetry (SAP) and optic nerve and macular imaging using Cirrus Spectral Domain Optical Coherence Tomography (SDOCT). Glaucoma was defined as repeatable abnormal SAP or progressive glaucomatous changes on stereo photographs. Pupil responses were assessed using an automated pupillometer, which records the magnitude of RAPD (RAPD score), with additional RAPD scores recorded for each of a series of colored stimuli (blue, red, green, and yellow). The relationship between RAPD score and intereye differences (right minus left eye) in circumpapillary retinal nerve fiber layer (cpRNFL) thickness, mGCIPL, macular thickness, and SAP mean deviation (MD), was examined using linear regression. RESULTS. There was fair correlation between RAPD score and asymmetric macular structural damage measured by intereye difference in mGCIPL thickness (R-2 = 0.285, P < 0.001). The relationship between RAPD score and intereye difference in macular thickness was weaker (R-2 = 0.167, P < 0.001). Intereye difference in cpRNFL thickness (R-2 = 0.350, P < 0.001) and SAP MD (R-2 = 0.594, P < 0.001) had stronger association with RAPD scores compared to intereye difference in mGCIPL and macular thickness. CONCLUSIONS. Objective assessment of pupillary responses using a pupillometer was associated with asymmetric macular structural damage in patients with glaucoma.en
dc.description.affiliationUniv Calif San Diego, Hamilton Glaucoma Ctr, 9500 Gilman Dr, La Jolla, CA 92093 USA
dc.description.affiliationUniv Calif San Diego, Dept Ophthalmol, La Jolla, CA 92093 USA
dc.description.affiliationUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.affiliationUniv Edinburgh, Princess Alexandra Eye Pavil, Edinburgh EH8 9YL, Midlothian, Scotland
dc.description.affiliationUniv Edinburgh, Dept Ophthalmol, Edinburgh EH8 9YL, Midlothian, Scotland
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institutes of Health/National Eye Institute
dc.description.sponsorshipResearch to Prevent Blindness (New York, NY, USA)
dc.description.sponsorshipAlcon
dc.description.sponsorshipAllergan
dc.description.sponsorshipPfizer
dc.description.sponsorshipMerck
dc.description.sponsorshipSanten
dc.description.sponsorshipBrazilian National Research Council-CAPES
dc.description.sponsorshipIDNIH/NEI: EY021818
dc.description.sponsorshipIDNIH/NEI: EY11008
dc.description.sponsorshipIDNIH/NEI: EY14267
dc.description.sponsorshipIDNIH/NEI: EY019869
dc.description.sponsorshipIDNIH/NEI: P30EY022589
dc.description.sponsorshipIDCAPES: 12309-13-3
dc.format.extent1738-1746
dc.identifierhttp://dx.doi.org/10.1167/iovs.15-18079
dc.identifier.citationInvestigative Ophthalmology & Visual Science. Rockville, v. 57, n. 4, p. 1738-1746, 2016.
dc.identifier.doi10.1167/iovs.15-18079
dc.identifier.fileWOS000375926700028.pdf
dc.identifier.issn0146-0404
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56098
dc.identifier.wosWOS:000375926700028
dc.language.isoeng
dc.publisherAssoc Research Vision Ophthalmology Inc
dc.relation.ispartofInvestigative Ophthalmology & Visual Science
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectpupillary responseen
dc.subjectpupillary reflexen
dc.subjectglaucomaen
dc.subjectmaculaen
dc.subjectstructural damageen
dc.titleAsymmetric Macular Structural Damage Is Associated With Relative Afferent Pupillary Defects in Patients With Glaucomaen
dc.typeinfo:eu-repo/semantics/article
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