Early physical exercise and seizure susceptibility later in life

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dc.contributor.authorSilva, Sergio Gomes da [UNIFESP]
dc.contributor.authorAlmeida, Alexandre Aparecido de [UNIFESP]
dc.contributor.authorSilva Araujo, Bruno Henrique [UNIFESP]
dc.contributor.authorScorza, Fulvio Alexandre [UNIFESP]
dc.contributor.authorCavalheiro, Esper Abrao [UNIFESP]
dc.contributor.authorArida, Ricardo Mario [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:17:31Z
dc.date.available2016-01-24T14:17:31Z
dc.date.issued2011-12-01
dc.description.abstractWe conducted a study to examine whether physical exercise undertaken during the period of postnatal brain development could modify seizure susceptibility later in life. Male Wistar rats aged 21 postnatal days (P21) were divided into two groups: exercise and control. Animals in the exercise group were submitted to daily exercise on the treadmill between P21 and P60. Running time and speed gradually increased over this period, reaching a maximum of 18 m/min for 60min. After the final exercise session (P60), animals from exercise group were maintained non-trained for 90 days. This period without stimulus was used to observe the influence of early physical exercise on susceptibility to seizures induced by the pilocarpine model of epilepsy at P150. the results showed that the exercise program undertaken during the period of postnatal brain development delayed the onset and reduced the intensity of pilocarpine-induced motor symptoms in midlife rats. These findings suggest that early exercise interferes positively in the later ictogenesis process, and support the hypothesis that physical activity in early life may build a neural reserve against brain disorders. (C) 2011 ISDN. Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Fisiol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Neurol & Neurosurg, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Fisiol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Neurol & Neurosurg, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCooperacao Interinstitucional de Apoio a Pesquisa sobre o Cerebro (CInAPCe)
dc.description.sponsorshipInstituto Nacional de Neurociencia Translacional (INNT) (Brazil)
dc.format.extent861-865
dc.identifierhttp://dx.doi.org/10.1016/j.ijdevneu.2011.07.011
dc.identifier.citationInternational Journal of Developmental Neuroscience. Oxford: Pergamon-Elsevier B.V., v. 29, n. 8, p. 861-865, 2011.
dc.identifier.doi10.1016/j.ijdevneu.2011.07.011
dc.identifier.issn0736-5748
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34290
dc.identifier.wosWOS:000297775100011
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Journal of Developmental Neuroscience
dc.rightsAcesso restrito
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectExerciseen
dc.subjectDevelopmenten
dc.subjectBrainen
dc.subjectPlasticityen
dc.subjectSeizureen
dc.subjectEpilepsyen
dc.titleEarly physical exercise and seizure susceptibility later in lifeen
dc.typeArtigo
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