The association of testosterone, sleep, and sexual function in men and women

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dc.contributor.authorAndersen, Monica L. [UNIFESP]
dc.contributor.authorAlvarenga, Tathiana F. [UNIFESP]
dc.contributor.authorMazaro-Costa, Renata
dc.contributor.authorHachul, Helena C. [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.date.accessioned2016-01-24T14:17:19Z
dc.date.available2016-01-24T14:17:19Z
dc.date.issued2011-10-06
dc.description.abstractTestosterone has been the focus of several investigations and review studies in males, but few have addressed its effects on sleep and sexual function, despite evidence of its androgenic effects on circadian activity in both sexes. Studies have been conducted to understand how sleeping increases (and how waking decreases) testosterone levels and how this rhythm can be related to sexual function. This review addresses the inter-relationships among testosterone, sexual function and sleep, including sleep-disordered breathing in both sexes, specifically its effects related to sleep deprivation. in addition, hormonal changes in testosterone that occur in the gonadal and adrenal axis with obstructive sleep apnea and other conditions of chronic sleep deprivation, and which consequently affect sexual life, have also been explored. Nevertheless, hormone-associated sleep disruptions occur across a lifetime, particularly in women. the association between endogenous testosterone and sex, sleep and sleep disturbances is discussed, including the results of clinical trials as well as animal model studies. Evidence of possible pathophysiological mechanisms underlying this relationship is also described. Unraveling the associations of sex steroid hormone concentrations with sleep and sexual function may have clinical implications, as sleep loss reduces testosterone levels in males, and low sex steroid hormone concentrations have been associated with sexual dysfunction. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ginecol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniv Fed Goias, Dept Ciencias Fisiol, Goiania, Go, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ginecol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 98/14.303-3
dc.description.sponsorshipIDFAPESP: 09/14206-4
dc.description.sponsorshipIDFAPESP: 09/01030-5
dc.format.extent80-104
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2011.07.060
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 1416, p. 80-104, 2011.
dc.identifier.doi10.1016/j.brainres.2011.07.060
dc.identifier.issn0006-8993
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34141
dc.identifier.wosWOS:000295708600009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectTestosteroneen
dc.subjectSleepen
dc.subjectSexual functionen
dc.subjectMenen
dc.subjectWomenen
dc.subjectClimactericen
dc.subjectAndrogenen
dc.subjectSleep deprivationen
dc.subjectErectionen
dc.subjectRatsen
dc.subjectAnimal modelen
dc.titleThe association of testosterone, sleep, and sexual function in men and womenen
dc.typeinfo:eu-repo/semantics/article
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