Drusen detection by confocal aperture-modulated infrared scanning laser ophthalmoscopy

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dc.contributor.authorDiniz, Bruno [UNIFESP]
dc.contributor.authorRibeiro, Ramiro M.
dc.contributor.authorRodger, Damien C.
dc.contributor.authorMaia, Mauricio [UNIFESP]
dc.contributor.authorSadda, SriniVas
dc.contributor.institutionDoheny Eye Inst
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Evangel Curitiba
dc.contributor.institutionUniv So Calif
dc.date.accessioned2016-01-24T14:31:22Z
dc.date.available2016-01-24T14:31:22Z
dc.date.issued2013-03-01
dc.description.abstractAim To evaluate the efficiency of drusen detection by scanning laser ophthalmoscopy (SLO) using various infrared confocal apertures and differential contrast (DC) strategies.Methods 11 eyes with non-neovascular age-related macular degeneration (AMD) underwent infrared imaging with a Nidek F-10 confocal SLO using multiple confocal apertures: central, ring, aperture on the right side (AR) and left side (AL), with and without use of the DC. A conventional colour fundus photograph was also obtained. Images were exported into a certified grading tool and all visible drusen were manually outlined by two graders. for each image type, the number of drusen and total drusen area were calculated, and the measurements obtained by the two graders were averaged. Intergrader reliability was evaluated, and paired t tests compared measurements between the various aperture/DC modes and the colour image.Results Agreement between graders was high (r=0.93-0.98). Drusen number values obtained with the AR (121.0, p=0.01) mode were higher than for the colour photographs (69.1). Area measurements were also significantly higher in the AR (1.93 mm(2); p=0.04) and AL modes (1.41 mm(2); p=0.03) when compared with the colour photographs (1.24 mm(2)). the addition of the DC did not seem to improve drusen detection compared with the unmodified infrared images.Conclusions in this pilot study, drusen number and area grades were significantly higher using the AR and AL in which the laterally scattered light is captured (retromode). Use of the lateral confocal aperture may highlight subclinical drusen and aid in monitoring disease progression and response to emerging non-neovascular AMD therapies.en
dc.description.affiliationDoheny Eye Inst, Dept Ophthalmol, Los Angeles, CA 90033 USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationHosp Evangel Curitiba, Curitiba, Parana, Brazil
dc.description.affiliationUniv So Calif, Keck Sch Med, Dept Ophthalmol, Los Angeles, CA 90033 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNEI
dc.description.sponsorshipBeckman Institute for Macular Research
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent285-290
dc.identifierhttp://dx.doi.org/10.1136/bjophthalmol-2012-302575
dc.identifier.citationBritish Journal of Ophthalmology. London: Bmj Publishing Group, v. 97, n. 3, p. 285-290, 2013.
dc.identifier.doi10.1136/bjophthalmol-2012-302575
dc.identifier.issn0007-1161
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36064
dc.identifier.wosWOS:000315162500010
dc.language.isoeng
dc.publisherBmj Publishing Group
dc.relation.ispartofBritish Journal of Ophthalmology
dc.rightsAcesso restrito
dc.titleDrusen detection by confocal aperture-modulated infrared scanning laser ophthalmoscopyen
dc.typeArtigo
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