Neonatal necrotizing enterocolitis rat model attenuated by a remote ischemic preconditioning in the pregnant

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dc.citation.issue3
dc.citation.volume32
dc.contributor.authorLuciano Gomes, Rudnei de Oliveira [UNIFESP]
dc.contributor.authorNeto, Ricardo Artigiani [UNIFESP]
dc.contributor.authorGuimaraes Neto, Jose de Freitas [UNIFESP]
dc.contributor.authorNunes, Adriana Porto [UNIFESP]
dc.contributor.authorde Souza Montero, Edna Frasson [UNIFESP]
dc.contributor.authorMartins, Jose Luiz [UNIFESP]
dc.coverageSao Paulo
dc.date.accessioned2020-07-17T14:02:44Z
dc.date.available2020-07-17T14:02:44Z
dc.date.issued2017
dc.description.abstractPurpose: To evaluate the effect of remote ischemic preconditioning (r-IPC) administered to pregnant rats, in the ileum of newborn rats subjected to hypoxia and reoxygenation. Methods: We used three pregnant rats and their newborn rats distributed in three groups: 1) Control (C) - Newborn rats born from a pregnant rat which did not undergo any interventionen
dc.description.abstract2) Hypoxia-Reoxygenation (H/R) - Newborn rats born from a pregnant rat which did not undergo any intervention, and were subjected to hypoxia-reoxygenationen
dc.description.abstract3) Remote Ischemic Preconditioning (r-IPC) - newborn rats born from a pregnant rat which was subjected to remote ischemic preconditioning twenty-four hours before giving birth and the newborn rats were subjected to hypoxia-reoxygenation. Segments of ileum were prepared for histological analysis by HE and immunohistochemistry by the Ki67 to evaluate cell proliferation, crypt depth and villus height and evaluation of apoptosis by cleaved caspase-3. Results: The intensity of the lesions was lower in the r-IPC than in the H/R group, showing significant difference (p<0.01). The r-IPC group showed a higher proliferative activity compared to the H/R group (p<0.01), with deeper crypts (r-IPC > H/R - p < 0.05), and higher villi, showing significant difference (r-IPC > H/R - (p < 0.01). The occurrence of apoptosis in the H/R group was lower in comparison to groups C and r-IPC, with significant difference (H/R < r-IPCen
dc.description.abstractp<0.05). Conclusion: The remote ischemic preconditioning applied to the pregnant rat protected the ileum of newborn rats subjected to hypoxia and reoxygenation, with decreased intensity of the lesions in the ileum mucosa and preservation of proliferative activity, keeping the villus height and crypt depth similar to group C.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Postgrad Program Interdisciplinary Surg Sci, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pathol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Dept Surg, Lab Surg Physiopathol LIM 62, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Surg, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pediat Surg, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Pediat Surg Res Lab, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Postgrad Program Interdisciplinary Surg Sci, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pathol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Surg, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pediat Surg, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Pediat Surg Res Lab, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent236-242
dc.identifierhttp://dx.doi.org/10.1590/S0102-865020170030000008
dc.identifier.citationActa Cirurgica Brasileira. Sao Paulo, v. 32, n. 3, p. 236-242, 2017.
dc.identifier.doi10.1590/S0102-865020170030000008
dc.identifier.fileWOS000399082900008.pdf
dc.identifier.issn0102-8650
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54981
dc.identifier.wosWOS:000399082900008
dc.language.isoeng
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEnterocolitis, Necrotizingen
dc.subjectIschemic Preconditioningen
dc.subjectPregnancy, Animalen
dc.subjectRatsen
dc.titleNeonatal necrotizing enterocolitis rat model attenuated by a remote ischemic preconditioning in the pregnanten
dc.typeinfo:eu-repo/semantics/article
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