Neurocognitive function in patients with residual excessive sleepiness from obstructive sleep apnea: a prospective, controlled study

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dc.citation.volume26
dc.contributor.authorWerli, Ksdy Sousa [UNIFESP]
dc.contributor.authorOtuyama, Leonardo Jun [UNIFESP]
dc.contributor.authorBertolucci, Paulo Henrique Ferreira [UNIFESP]
dc.contributor.authorRizzi, Camila Furtado [UNIFESP]
dc.contributor.authorGuilleminault, Christian
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorPoyares, Dalva [UNIFESP]
dc.coverageAmsterdam
dc.date.accessioned2020-07-31T12:47:38Z
dc.date.available2020-07-31T12:47:38Z
dc.date.issued2016
dc.description.abstractObjective: This study aimed to evaluate neurocognitive function in adult patients with residual excessive sleepiness (RES) after appropriate treatment of obstructive sleep apnea (OSA) with CPAP and good adherence to treatment. Methods: This was a prospective controlled study. We included patients of both sexes, aged 35-60 years with OSA and an apnea-hypopnea index>20 ev/h, effectively treated with CPAP, but with a residual Epworth Sleepiness Scale score >= 11. The control group consisted of OSA patients adequately treated with CPAP who did not present with excessive sleepiness after treatment. Both groups underwent the following evaluations: polysomnography, multiple sleep latency testing, depression symptoms, and cognitive assessment. Results: Regarding baseline characteristics, the data were matched for age, years of study, and body mass index. Long-term memory result did not show a significant difference between the two groups (RES group 4.7 +/- 2.0en
dc.description.abstractcontrol group 6.5 +/- 1.9en
dc.description.abstractp = 0.08). The executive functions were the most affected, with alterations in Wisconsin test, number of categories (RES group: 1.6 +/- 1.4en
dc.description.abstractcontrol group: 3.0 +/- 1.4en
dc.description.abstractp = 0.01), and semantic verbal fluency test (RES group: 13.6 +/- 3.3en
dc.description.abstractcontrol group: 16.9 +/- 4.3en
dc.description.abstractp = 0.04). Conclusion: In summary, the mean depression scale score in the group with residual excessive sleepiness was significantly higher than that in the control group. Patients with residual excessive sleepiness showed impairment of executive functions but no impairments in other cognitive domains. (C) 2016 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, Rua Napoleao de Barros 925,2nd Floor, BR-04024002 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Neurol, Sao Paulo, Brazil
dc.description.affiliationStanford Univ, Sleep Disorders Ctr, Stanford, CA 94305 USA
dc.description.affiliationUnifespDepartment of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationUnifespDepartment of Neurology, Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociação Fundo de Incentivo à Psicofarmacologia (AFIP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent6-11
dc.identifierhttp://dx.doi.org/10.1016/j.sleep.2016.06.028
dc.identifier.citationSleep Medicine. Amsterdam, v. 26, p. 6-11, 2016.
dc.identifier.doi10.1016/j.sleep.2016.06.028
dc.identifier.issn1389-9457
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56952
dc.identifier.wosWOS:000390720900002
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofSleep Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectObstructive sleep apneaen
dc.subjectResidual excessive sleepinessen
dc.subjectCognitive functionsen
dc.titleNeurocognitive function in patients with residual excessive sleepiness from obstructive sleep apnea: a prospective, controlled studyen
dc.typeinfo:eu-repo/semantics/article
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