Resveratrol improves reproductive parameters of adult rats varicocelized in peripuberty

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dc.citation.issue1
dc.citation.volume152
dc.contributor.authorMendes, Talita Biude [UNIFESP]
dc.contributor.authorPaccola, Camila Cicconi [UNIFESP]
dc.contributor.authorde Oliveira Neves, Flavia Macedo [UNIFESP]
dc.contributor.authorSimas, Joana Nogueres [UNIFESP]
dc.contributor.authorVaz, Andre da Costa [UNIFESP]
dc.contributor.authorCabral, Regina Elisabeth L. [UNIFESP]
dc.contributor.authorVendramini, Vanessa [UNIFESP]
dc.contributor.authorMiraglia, Sandra Maria [UNIFESP]
dc.coverageBristol
dc.date.accessioned2020-08-14T13:44:27Z
dc.date.available2020-08-14T13:44:27Z
dc.date.issued2016
dc.description.abstractThe aim of this study was to investigate the protective action of resveratrol against the reproductive damage caused by left-sided experimental varicocele. There was a reduction of testicular major axis in the varicocele group when compared with the other groupsen
dc.description.abstractthe testicular volume was reduced in varicocele group in comparison to the sham-control and resveratrol groups. The frequency of morphologically abnormal sperm was higher in varicocele and varicocele treated with resveratrol groups than in sham-control and resveratrol groups. The frequency of sperm with 100% of mitochondrial activity and normal acrosome integrity were lower in varicocele group than in varicocele treated with resveratrol, sham-control and resveratrol groups. Sperm motility was also reduced in varicocele group than in other groups. The sperm DNA fragmentation was higher in varicocele group than in other groups. Testicular levels of malondialdehyde were higher in varicocele and varicocele treated with resveratrol groups. The varicocele and varicocele treated with resveratrol groups had a significantly higher frequency of TUNEL-positive cells than sham-control and resveratrol groupsen
dc.description.abstracthowever, immunolabeling of the testes from varicocele treated with resveratrol group showed a lower number of apoptotic germ cells in comparison with the left testis of rats of the varicocele group. Reproductive alterations produced by varicocele from peripuberty were reduced by resveratrol in adulthood. Resveratrol should be better investigated as an adjuvant in the treatment of varicocele. Daily administration of resveratrol to rats with varicocele from peripuberty improves sperm quality in the adulthood.en
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Morphol & Genet, Dev Biol Lab, Sao Paulo, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Morphol & Genet, Dev Biol Lab, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Council for the Improvement of Higher Education (CAPES/Brazil)
dc.description.sponsorshipLaboratory of Human Reproduction - Unifesp
dc.format.extent23-35
dc.identifierhttp://dx.doi.org/10.1530/REP-16-0025
dc.identifier.citationReproduction. Bristol, v. 152, n. 1, p. 23-35, 2016.
dc.identifier.doi10.1530/REP-16-0025
dc.identifier.fileWOS000379551900006.pdf
dc.identifier.issn1470-1626
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57676
dc.identifier.wosWOS:000379551900006
dc.language.isoeng
dc.publisherBioscientifica Ltd
dc.relation.ispartofReproduction
dc.rightsAcesso aberto
dc.titleResveratrol improves reproductive parameters of adult rats varicocelized in peripubertyen
dc.typeArtigo
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