A preponderantly 4-sulfated, 3-linked galactan from the green alga Codium isthmocladum

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dc.contributor.authorFarias, Eduardo Henrique Cunha de [UNIFESP]
dc.contributor.authorPomin, Vitor Hugo
dc.contributor.authorValente, Ana-Paula
dc.contributor.authorNader, Helena Bociani [UNIFESP]
dc.contributor.authorRocha, Hugo Alexandre de Oliveira
dc.contributor.authorMourao, Paulo Antonio de Souza
dc.contributor.institutionUniv Fed Rio Grande do Norte
dc.contributor.institutionHosp Univ Clementino Fraga Filho
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:49:35Z
dc.date.available2016-01-24T13:49:35Z
dc.date.issued2008-03-01
dc.description.abstractThe green algae of the genus Codium have recently been demonstrated to be an important source of sulfated galactans from the marine environment. Here, a sulfated galactan was isolated from the species Codium isthmocladum and its structure was studied by a combination of chemical analyses and NMR spectroscopy. Two fractions (SG 1, similar to 14 kDa, and SG 2, similar to 20 kDa) were derived from this highly polydisperse and heterogeneous polysaccharide. Both exhibited similar structures in (1)H1D NMR spectra. the structural features of SG 2 and its desulfated derivative were analyzed by COSY, TOCSY, DEPT-HSQC, HSQC, and HMBC. This sulfated galactan is composed preponderantly of 4-sulfated, 3-linked beta-D-galactopyranosyl units. in minor amounts, it is sulfated and glycosylated at C-6. Pyruvate groups are also found, forming five-membered cyclic ketals as 3,4-O-(1' carboxy)ethylidene-beta-D-galactose residues. A comparison of sulfated galactans from different marine taxonomic groups revealed similar backbones of 3-beta-D-Galp-1.en
dc.description.affiliationUniv Fed Rio Grande do Norte, Dept Bioquim, BIOPOL, Lab Biotechnol Polimeros Nat, BR-59072970 Natal, RN, Brazil
dc.description.affiliationHosp Univ Clementino Fraga Filho, Lab Tecido Conjuntivo, Natal, RN, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Bioquim Med, Ctr Ciencias Saude, BR-21941590 Rio de Janeiro, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Ctr Nacl Ressonancia Magnet Nucl Jiri Jonas, BR-21941590 Rio de Janeiro, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Bioquim, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Bioquim, BR-04044020 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent250-259
dc.identifierhttps://dx.doi.org/10.1093/glycob/cwm139
dc.identifier.citationGlycobiology. Cary: Oxford Univ Press Inc, v. 18, n. 3, p. 250-259, 2008.
dc.identifier.doi10.1093/glycob/cwm139
dc.identifier.issn0959-6658
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/30456
dc.identifier.wosWOS:000253832400007
dc.language.isoeng
dc.publisherOxford Univ Press Inc
dc.relation.ispartofGlycobiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html
dc.subjectCodium isthmocladumen
dc.subjectGreen algaen
dc.subjectGreen seaweeden
dc.subjectPhylogenyen
dc.subjectPyruvylated-sulfated galactanen
dc.titleA preponderantly 4-sulfated, 3-linked galactan from the green alga Codium isthmocladumen
dc.typeinfo:eu-repo/semantics/article
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