Early developmental exposure to high fructose intake in rats with NaCl stimulation causes cardiac damage

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dc.citation.issue1
dc.citation.volume55
dc.contributor.authorAraujo, I. C. [UNIFESP]
dc.contributor.authorAndrade, R. P.
dc.contributor.authorSantos, F.
dc.contributor.authorSoares, E. S.
dc.contributor.authorYokota, R. [UNIFESP]
dc.contributor.authorMostarda, C.
dc.contributor.authorFiorino, P.
dc.contributor.authorDe Angelis, K.
dc.contributor.authorIrigoyen, M. C.
dc.contributor.authorMorris, M.
dc.contributor.authorFarah, V. [UNIFESP]
dc.coverageHeidelberg
dc.date.accessioned2020-10-30T18:46:30Z
dc.date.available2020-10-30T18:46:30Z
dc.date.issued2016
dc.description.abstractMetabolic syndrome (MS) increases the risk of type 2 diabetes and cardiovascular disease. High consumption of fructose is a proposed cause of increased MS, manifested through hypertension, obesity, insulin resistance, and dyslipidemia. High NaCl also increases the risk of CD. The purpose of this study is to evaluate the influence of fructose and sodium on autonomic dysfunction and its relation with CD in MS. Fructose overload was started at weaning and continued through adulthood. Male Wistar rats (21 days) were divided into four groups: Control (C), fructose consumption (10 %, F), NaCl consumption (salt 1 % for the 10 last days, S), and fructose and NaCl (FS), and monitored for 8 weeks. Metabolic evaluations consisted of Lee index, glycemia, insulin and glucose tolerance tests, triglycerides, and total cholesterol measurements. Cardiovascular parameters measured were arterial pressure (AP) and cardiac function performed by echocardiography. They also measured the influence of renin angiotensin (RAS) and autonomic nervous systems by drug blockage with losartan, atropine, and atenolol. Energy analysis showed no change between groups. Fructose overload induced a MS state, confirmed by insulin resistance, glucose intolerance, and dyslipidemia. Fasting glucose was increased in F and FS rat groups compared with C and S groups. AP was higher in F, S, and FS groups in comparison with the C group. The hypotensive response after sympathetic blockade was increased in F, S, and FS versus C. The cardiac vagal tonus was reduced in F and FS animal groups. The intrinsic heart rate was decreased in the FS group (372 +/- A 9 bpm) compared with the C group (410 +/- A 13 bpm). The morphometric measurements evaluated through left ventricular diameter during diastole and the left ventricular diameter during systole decreased in the FS group (16 and 26 %, respectively). Diastolic function was reduced in F and FS. The depressor response induced by losartan was increased in the F group in comparison with other groups. However, there was a uniform increase in plasma ACE activity in all treated groups compared with the C group. Data suggest that early exposure to high fructose intake produced marked alterations in metabolic and cardiovascular function. When stimulated by NaCl, the fructose-fed subjects showed further impairment in cardiac function.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Med, Translat Med Div, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Prebiteriana Mackenzie, Hlth & Biol Sci Ctr, Renal Cardiovasc & Metab Physiopharmacol Lab, Rua Consolacao 930, BR-01302907 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo FMUSP, Hypertens Unit, Heart Inst InCor, Sch Med, Ave Doutor Eneas de Carvalho Aguiar 44, BR-05403900 Sao Paulo, SP, Brazil
dc.description.affiliationFed Univ Maranhao UFMA, Sao Luis, MA, Brazil
dc.description.affiliationUniv Nove Julho UNINOVE, Translat Physiol Lab, Rua Vergueiro 235-249, BR-01504001 Sao Paulo, SP, Brazil
dc.description.affiliationNova SE Univ, Coll Osteopath Med, 3200 South Univ Dr, Ft Lauderdale, FL 33328 USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Med, Translat Med Div, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo
dc.description.sponsorshipNational Counsel of Technological and Scientific Development (CNPq)
dc.description.sponsorshipMackenzie University
dc.description.sponsorshipCoordination for the Improvement of Higher Education Personnel (CAPES)
dc.description.sponsorshipCAPES/FIPSE program
dc.description.sponsorshipIDFAPESP: 2009/52556-7
dc.format.extent83-91
dc.identifierhttps://doi.org/10.1007/s00394-014-0826-5
dc.identifier.citationEuropean Journal Of Nutrition. Heidelberg, v. 55, n. 1, p. 83-91, 2016.
dc.identifier.doi10.1007/s00394-014-0826-5
dc.identifier.issn1436-6207
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58491
dc.identifier.wosWOS:000369309700009
dc.language.isoeng
dc.publisherSpringer Heidelberg
dc.relation.ispartofEuropean Journal Of Nutrition
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCardiovascular risken
dc.subjectFructoseen
dc.subjectMetabolic syndromeen
dc.subjectRenin angiotensin systemen
dc.subjectNaClen
dc.titleEarly developmental exposure to high fructose intake in rats with NaCl stimulation causes cardiac damageen
dc.typeinfo:eu-repo/semantics/article
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