Hormone replacement therapy increases levels of antibodies against heat shock protein 65 and certain species of oxidized low density lipoprotein

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dc.contributor.authorUint, Luciana
dc.contributor.authorGebara, Otávio Celso Eluf
dc.contributor.authorPinto, Lígia B.
dc.contributor.authorWajngarten, Maurício
dc.contributor.authorBoschcov, Paulo [UNIFESP]
dc.contributor.authorLuz, Protásio Lemos da
dc.contributor.authorGidlund, Magnus
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:30:00Z
dc.date.available2015-06-14T13:30:00Z
dc.date.issued2003-04-01
dc.description.abstractHormone replacement therapy (HRT) reduces cardiovascular risks, although the initiation of therapy may be associated with transient adverse ischemic and thrombotic events. Antibodies against heat shock protein (Hsp) and oxidized low density lipoprotein (LDL) have been found in atherosclerotic lesions and plasma of patients with coronary artery disease and may play an important role in the pathogenesis of atherosclerosis. The aim of the present study was to assess the effects of HRT on the immune response by measuring plasma levels of antibodies against Hsp 65 and LDL with a low and high degree of copper-mediated oxidative modification of 20 postmenopausal women before and 90 days after receiving orally 0.625 mg equine conjugate estrogen plus 2.5 mg medroxyprogesterone acetate per day. HRT significantly increased antibodies against Hsp 65 (0.316 ± 0.03 vs 0.558 ± 0.11) and against LDL with a low degree of oxidative modification (0.100 ± 0.01 vs 0.217 ± 0.02) (P<0.05 and P<0.001, respectively, ANOVA). The hormone-mediated immune response may trigger an inflammatory response within the vessel wall and potentially increase plaque burden. Whether or not this immune response is temporary or sustained and deleterious requires further investigation.en
dc.description.affiliationUniversidade de São Paulo Faculdade de Medicina Instituto do Coração
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Biofísica
dc.description.affiliationUniversidade de São Paulo Instituto de Ciências Biomédicas IV Departamento de Imunologia and Instituto de Medicina Tropical da Universidade de São Paulo
dc.description.affiliationUnifespUNIFESP, Depto. de Biofísica
dc.description.sourceSciELO
dc.format.extent491-494
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2003000400011
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 4, p. 491-494, 2003.
dc.identifier.doi10.1590/S0100-879X2003000400011
dc.identifier.fileS0100-879X2003000400011.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2003000400011
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/1707
dc.identifier.wosWOS:000182664000011
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsAcesso aberto
dc.subjectHormone replacement therapyen
dc.subjectPostmenopauseen
dc.subjectOxidized LDLen
dc.subjectHeat shock proteinen
dc.subjectImmune responseen
dc.subjectAntibodiesen
dc.titleHormone replacement therapy increases levels of antibodies against heat shock protein 65 and certain species of oxidized low density lipoproteinen
dc.typeArtigo
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