Improvement in HOMA-IR is an independent predictor of reduced carotid intima-media thickness in obese adolescents participating in an interdisciplinary weight-loss program

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dc.contributor.authorSanches, Priscila de Lima [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorElias, Natalia
dc.contributor.authorFonseca, Francisco Antonio Helfenstein [UNIFESP]
dc.contributor.authorPiano, Aline de [UNIFESP]
dc.contributor.authorCarnier, June [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorTock, Lian [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorDâmaso, Ana Raimunda [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:06:09Z
dc.date.available2016-01-24T14:06:09Z
dc.date.issued2011-02-01
dc.description.abstractThe aim of this study was to verify whether a 1-year interdisciplinary weight-loss program improved common carotid artery intima-media thickness (IMT) and whether insulin resistance and/or inflammation (as measured by the markers plasminogen activator inhibitor type-1 and adiponectin) might underlie obesity in adolescents. A group of 29 post-pubescent obese adolescents were submitted to an interdisciplinary intervention over the course of 1 year. Common carotid artery IMT was determined ultrasonographically. Body composition, blood pressure (BP), glycemia, insulinemia, homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile and adipokine concentrations were analyzed before and after the intervention. the interdisciplinary weight-loss program promoted a significant improvement in body composition, insulin concentration, HOMA-IR, lipid profile, BP and inflammatory state, in addition to significantly decreasing the common carotid artery IMT. Furthermore, this study demonstrated that the difference between baseline and final values of HOMA-IR (Delta HOMA-IR) was negatively correlated with concomitant changes in the adiponectin concentration (Delta adiponectin; r=-0.42; P=0.02) and positively correlated with changes in common carotid artery IMT (Delta carotid IMT; r=0.41; P=0.03). Multiple regression analysis adjusted by age, cardiovascular risk factors and inflammatory markers showed that Delta HOMA-IR was an independent predictor of significant changes in common carotid artery IMT. This investigation demonstrated that an interdisciplinary weight-loss program promoted a reduction of the common carotid artery IMT in obese Brazilian adolescents, and the improvement of HOMA-IR was an independent predictor of carotid IMT changes in this population. Hypertension Research (2011) 34, 232-238; doi: 10.1038/hr.2010.225; published online 2 December 2010en
dc.description.affiliationUniversidade Federal de São Paulo, Postgrad Program Nutr, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Div Cardiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biosci, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Postgrad Program Nutr, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Div Cardiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAFIP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipCENESP
dc.description.sponsorshipFADA
dc.description.sponsorshipUNIFESP-EPM
dc.description.sponsorshipIDFAPESP: 2006/00684-3
dc.description.sponsorshipIDFAPESP: 2008/53069-0
dc.description.sponsorshipIDFAPESP: 9814303-3 S.T
dc.format.extent232-238
dc.identifierhttps://dx.doi.org/10.1038/hr.2010.225
dc.identifier.citationHypertension Research. London: Nature Publishing Group, v. 34, n. 2, p. 232-238, 2011.
dc.identifier.doi10.1038/hr.2010.225
dc.identifier.issn0916-9636
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/33428
dc.identifier.wosWOS:000287020000016
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofHypertension Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAdiponectinen
dc.subjectAtherosclerosisen
dc.subjectInflammationen
dc.subjectObesityen
dc.subjectPAI-1en
dc.titleImprovement in HOMA-IR is an independent predictor of reduced carotid intima-media thickness in obese adolescents participating in an interdisciplinary weight-loss programen
dc.typeinfo:eu-repo/semantics/article
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