Absence-like seizures in adult rats following pilocarpine-induced status epilepticus early in life

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dc.contributor.authorFerreira, B.l.c. [UNIFESP]
dc.contributor.authorValle, A.c.
dc.contributor.authorCavalheiro, Esper Abrão [UNIFESP]
dc.contributor.authorTimo-iaria, C.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:30:11Z
dc.date.available2015-06-14T13:30:11Z
dc.date.issued2003-12-01
dc.description.abstractAdministration of pilocarpine causes epilepsy in rats if status epilepticus (SE) is induced at an early age. To determine in detail the electrophysiological patterns of the epileptogenic activity in these animals, 46 Wistar rats, 7-17 days old, were subjected to SE induced by pilocarpine and electro-oscillograms from the cortex, hippocampus, amygdala, thalamus and hypothalamus, as well as head, rostrum and vibrissa, eye, ear and forelimb movements, were recorded 120 days later. Six control animals of the same age range did not show any signs of epilepsy. In all the rats subjected to SE, iterative spike-wave complexes (8.1 ± 0.5 Hz in frequency, 18.9 ± 9.1 s in duration) were recorded from the frontal cortex during absence fits. However, similar spike-wave discharges were always found also in the hippocampus and, less frequently, in the amygdala and in thalamic nuclei. Repetitive or single spikes were also detected in these same central structures. Clonic movements and single jerks were recorded from all the rats, either concomitantly with or independently of the spike-wave complexes and spikes. We conclude that rats made epileptic with pilocarpine develop absence seizures also occurring during paradoxical sleep, showing the characteristic spike-wave bursts in neocortical areas and also in the hippocampus. This is in contrast to the well-accepted statement that one of the main characteristics of absence-like fits in the rat is that spike-wave discharges are never recorded from the hippocampal fields.en
dc.description.affiliationUniversidade de São Paulo Faculdade de Medicina Laboratório de Neurocirurgia Funcional
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Laboratório de Neurologia Experimental
dc.description.affiliationUnifespUNIFESP, EPM, Laboratório de Neurologia Experimental
dc.description.sourceSciELO
dc.format.extent1685-1694
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2003001200010
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 12, p. 1685-1694, 2003.
dc.identifier.doi10.1590/S0100-879X2003001200010
dc.identifier.fileS0100-879X2003001200010.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2003001200010
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/1913
dc.identifier.wosWOS:000187175000010
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsAcesso aberto
dc.subjectEpilepsyen
dc.subjectAbsence seizuresen
dc.subjectSpike-waveen
dc.subjectStatus epilepticusen
dc.subjectPilocarpineen
dc.titleAbsence-like seizures in adult rats following pilocarpine-induced status epilepticus early in lifeen
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