Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function

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dc.contributor.authorBrum, Patricia Chakur
dc.contributor.authorBacurau, Aline Villa Nova
dc.contributor.authorMedeiros, Alessandra [UNIFESP]
dc.contributor.authorFerreira, Julio Cesar Batista
dc.contributor.authorVanzelli, Andréa Somolanji
dc.contributor.authorNegrao, Carlos Eduardo
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionStanford Univ
dc.date.accessioned2018-06-15T16:24:03Z
dc.date.available2018-06-15T16:24:03Z
dc.date.issued2011-09-01
dc.description.abstractHeart failure is a common endpoint for many forms of cardiovascular disease and a significant cause of morbidity and mortality. Chronic neurohumoral excitation (i.e., sympathetic hyperactivity) has been considered to be a hallmark of heart failure and is associated with a poor prognosis, cardiac dysfunction and remodeling, and skeletal myopathy. Aerobic exercise training is efficient in counteracting sympathetic hyperactivity and its toxic effects on cardiac and skeletal muscles. In this review, we describe the effects of aerobic exercise training on sympathetic hyperactivity, skeletal myopathy, as well as cardiac function and remodeling in human and animal heart failure. We also discuss the mechanisms underlying the effects of aerobic exercise training.en
dc.description.affiliationUniv Sao Paulo, Dept Biodinam Movimento Corpo Humano, Escola Educ Fis & Esporte, BR-05508900 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil
dc.description.affiliationStanford Univ, Dept Chem & Syst Biol, Palo Alto, CA 94304 USA
dc.description.affiliationUniv Sao Paulo, Fac Med, Inst Coracao, BR-05508900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.description.sponsorshipIDFAPESP: 2002/04558-8pt
dc.description.sponsorshipIDFAPESP: 2005/59740-7pt
dc.description.sponsorshipIDFAPESP: 2006/61523-7pt
dc.description.sponsorshipIDFAPESP: 2008/50777-3pt
dc.description.sponsorshipIDFAPESP 2009/03143-1pt
dc.description.sponsorshipIDCNPq: 473251/2009-4pt
dc.description.sponsorshipIDCNPq: BPQ 301519/2008-0pt
dc.format.extent827-835
dc.identifierhttps://dx.doi.org/10.1590/S0100-879X2011007500075
dc.identifier.citationBrazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 44, n. 9, p. 827-835, 2011.
dc.identifier.fileS0100-879X2011000900002.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2011000900002
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/43136
dc.identifier.wosWOS:000295721500002
dc.language.isoeng
dc.publisherAssoc Bras Divulg Cientifica
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHeart failureen
dc.subjectExercise trainingen
dc.subjectSympathetic hyperactivityen
dc.subjectVentricular functionen
dc.subjectCardiac remodelingen
dc.subjectSkeletal myopathyen
dc.titleAerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle functionen
dc.typeinfo:eu-repo/semantics/article
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