Heteropteris aphrodisiaca O. Machado: Effects of extract BST 0298 on the oxidative stress of young and old rat brains

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dc.contributor.authorMattei, R.
dc.contributor.authorBarros, M. P.
dc.contributor.authorGalvao, SMP
dc.contributor.authorBechara, EJH
dc.contributor.authorCarlini, ELD
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T12:31:31Z
dc.date.available2016-01-24T12:31:31Z
dc.date.issued2001-11-01
dc.description.abstractThe plant Heteropteris aphrodisiaca O. Machado is widely employed in Brazilian popular medicine as a stimulant, a tonic and a remedy for nervous debility. Several other plant products with similar therapeutic applications may have such effects based on the antioxidant content of polyphenols (gallates, cathecols, etc.) and flavonoids. the aim of this work was to investigate the effects of Heteropteris aphrodisiaca O. Machado extracts on the antioxidant defences and oxidative stress of young and old rat brains. Tests of lipoperoxidation in vitro, comparing H. aphrodisiaca extracts with butylhydroxytoluene (BHT), a classic antioxidant, showed an efficient inhibition of lipoperoxidation (Q(1/2) = 3.3 mug/mL). Chronic treatment of young and old rats with 50 mg plant extract/kg body weight resulted in a significant increase in superoxide dismutase (SOD) activities (40%) in the brain of old rats, but no changes in catalase and glutathione peroxidase (GPX). No significant variations in antioxidant enzyme activities were observed in the brains of young rats. However, significantly lower levels of lipoperoxidation (30%) were detected in the brain of young rats upon plant extract administration, suggesting that H. aphrodisiaca extracts reduced the oxidative stress to brain lipids. Copyright (C) 2001 John Wiley & Sons, Ltd.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Bioquim, BR-05508 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent604-607
dc.identifierhttp://dx.doi.org/10.1002/ptr.838
dc.identifier.citationPhytotherapy Research. Malden: Wiley-Blackwell, v. 15, n. 7, p. 604-607, 2001.
dc.identifier.doi10.1002/ptr.838
dc.identifier.issn0951-418X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26651
dc.identifier.wosWOS:000171909300009
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofPhytotherapy Research
dc.rightsAcesso restrito
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectHeteropteris aphrodisiacaen
dc.subjectlipid peroxidationen
dc.subjectoxidative stressen
dc.subjectfree radicalsen
dc.subjectagingen
dc.subjectrat brainen
dc.titleHeteropteris aphrodisiaca O. Machado: Effects of extract BST 0298 on the oxidative stress of young and old rat brainsen
dc.typeArtigo
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