Effects of APOE haplotypes and measures of cardiovascular risk over gender-dependent cognitive and functional changes in one year in Alzheimer's disease

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dc.citation.issue5
dc.citation.volume128
dc.contributor.authorde Oliveira, Fabricio Ferreira [UNIFESP]
dc.contributor.authorPereira, Fernando Vieira [UNIFESP]
dc.contributor.authorKamikado Pivi, Glaucia Akiko [UNIFESP]
dc.contributor.authorSmith, Marilia Cardoso [UNIFESP]
dc.contributor.authorFerreira Bertolucci, Paulo Henrique [UNIFESP]
dc.coverageAbingdon
dc.date.accessioned2020-07-02T18:52:04Z
dc.date.available2020-07-02T18:52:04Z
dc.date.issued2018
dc.description.abstractBackground: Illiteracy, high cerebrovascular risk and copies of APOE-E4 are risk factors for Alzheimer's disease dementia (AD). We aimed to investigate the impacts of gender, education, coronary heart disease (CHD) risk and creatinine clearance variations, body mass index (BMI) and APOE haplotypes over the rates of cognitive and functional decline of AD in one year.Methods: Consecutive outpatients with late-onset AD were assessed for gender, schooling, BMI and APOE haplotypes, variations in one year of creatinine clearance and Framingham projections of the 10-year absolute CHD risk, and prospective scores of the Mini-Mental State Examination (MMSE), the Clinical Dementia Rating Sum-of-Boxes (CDR-SOB), the Index of Independence in Activities of Daily Living (ADL) and Lawton's Scale for Instrumental Activities of Daily Living (IADL).Results: For 191 patients, mean age at AD onset was 73.266.4 years-old, earlier for APOE-E4/E4 carriers (p = 0.0039). For women, higher BMI led to improvements in CDR-SOB ( = -0.091en
dc.description.abstractp = 0.037) and MMSE ( = 0.126en
dc.description.abstractp = 0.017) scores, while increased creatinine clearance was associated with improvements in ADL ( = 0.028en
dc.description.abstractp = 0.012) and MMSE ( = 0.043en
dc.description.abstractp = 0.039) scores and higher schooling led to faster worsening of IADL ( = -0.195en
dc.description.abstractp = 0.022) scores. No variables impacted cognitive or functional decline for men, whereas copies of APOE-E4 and the CHD risk had no significant effects whatsoever.Conclusions: Higher BMI and creatinine clearance are protective regarding cognitive and functional decline for women, whereas higher cognitive reserve may lead to faster decline in instrumental functionality. APOE haplotypes affected the age at AD onset, but not cognitive or functional decline.en
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Neurol & Neurosurg, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Morphol & Genet, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Neurol & Neurosurg, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Morphol & Genet, Escola Paulista Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCAPES - Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior [1067/10]
dc.description.sponsorshipFAPESP - The State of Sao Paulo Research Foundation [2015/10109-5]
dc.description.sponsorshipIDCAPES [1067/10]
dc.description.sponsorshipIDFAPESP [2015/10109-5]
dc.format.extent472-476
dc.identifierhttp://dx.doi.org/10.1080/00207454.2017.1396986
dc.identifier.citationInternational Journal Of Neuroscience. Abingdon, v. 128, n. 5, p. 472-476, 2018.
dc.identifier.doi10.1080/00207454.2017.1396986
dc.identifier.issn0020-7454
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53859
dc.identifier.wosWOS:000425403000012
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofInternational Journal Of Neuroscience
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectActivities of daily livingen
dc.subjectAlzheimer diseaseen
dc.subjectcognitionen
dc.subjecteducational statusen
dc.subjectrisk factorsen
dc.titleEffects of APOE haplotypes and measures of cardiovascular risk over gender-dependent cognitive and functional changes in one year in Alzheimer's diseaseen
dc.typeinfo:eu-repo/semantics/article
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