The Mitogen-Activated Protein Kinase (MAPK) Pathway: Role in Immune Evasion by Trypanosomatids

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dc.citation.volume7
dc.contributor.authorSoares-Silva, Mercedes
dc.contributor.authorDiniz, Flavia F.
dc.contributor.authorGomes, Gabriela N.
dc.contributor.authorBahia, Diana [UNIFESP]
dc.coverageLausanne
dc.date.accessioned2020-08-21T17:00:22Z
dc.date.available2020-08-21T17:00:22Z
dc.date.issued2016
dc.description.abstractLeishrnania spp. and Trypanosome cruzi are the causative agents of leishmaniasis and Chagas disease, respectively, two neglected tropical diseases that affect about 25 million people worldwide. These parasites belong to the family Trypanosomatidae, and are both obligate intracellular parasites that manipulate host signaling pathways and the innate immune system to establish infection. Mitogen-activated protein kinases (MAPKs) are serine and threonine protein kinases that are highly conserved in eukaryotes, and are involved in signal transduction pathways that modulate physiological and pathophysiological cell responses. This mini-review highlights existing knowledge concerning the mechanisms that Leishmania spp. and T. cruzi have evolved to target the host's MAPK signaling pathways and highjack the immune response, and, in this manner, promote parasite maintenance in the host.en
dc.description.affiliationUniv Fed Minas Gerais, Inst Ciencias Biol, Dept Biol Gera, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCNPq fellowship
dc.description.sponsorshipFAPEMIG fellowship
dc.description.sponsorshipEAPEMIG
dc.description.sponsorshipFAPESP
dc.description.sponsorshipIDEAPEMIG: APQ-01674-14
dc.description.sponsorshipIDFAPESP: 07/50551-2
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fmicb.2016.00183
dc.identifier.citationFrontiers In Microbiology. Lausanne, v. 7, p. -, 2016.
dc.identifier.doi10.3389/fmicb.2016.00183
dc.identifier.fileWOS000370759200001.pdf
dc.identifier.issn1664-302X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57960
dc.identifier.wosWOS:000370759200001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Microbiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMAP kinaseen
dc.subjectTrypanosoma cruzien
dc.subjectLeishmaniaen
dc.subjectimmune evasion of parasitesen
dc.subjectcellular signalingen
dc.titleThe Mitogen-Activated Protein Kinase (MAPK) Pathway: Role in Immune Evasion by Trypanosomatidsen
dc.typeinfo:eu-repo/semantics/article
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