Tissue characterization and phenotype classification in patients presenting with acute myocardial infarction: Insights from the iWonder study

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dc.citation.issue7
dc.citation.volume90
dc.contributor.authorSouza, Cristiano F. [UNIFESP]
dc.contributor.authorMaehara, Akiko
dc.contributor.authorMintz, Gary S.
dc.contributor.authorMatsumura, Mitsuaki
dc.contributor.authorAlves, Claudia M. R. [UNIFESP]
dc.contributor.authorCarvalho, Antonio Carlos [UNIFESP]
dc.contributor.authorCaixeta, Adriano [UNIFESP]
dc.coverageHoboken
dc.date.accessioned2020-09-01T13:21:09Z
dc.date.available2020-09-01T13:21:09Z
dc.date.issued2017
dc.description.abstractObjectivesWe sought to assess a new modality of radiofrequency intravascular ultrasound (IVUS) called iMAP-IVUS (Boston Scientific, Santa Clara, California) during the evaluation of patients presenting with high-risk acute coronary syndromes. BackgroundThere are limited data on plaque tissue characterization and phenotype classification using iMAP-IVUS. MethodsIn the iWonder study patients presenting with ST-elevation myocardial infarction (STEMI) or non-STEMI underwent three-vessel grayscale IVUS and iMAP-IVUS tissue characterization prior to percutaneous intervention. In total 385 lesions from 100 patients were divided into culprit (n=100) and nonculprit (n=285) lesions. Lesion phenotype was classified as (i) thin-cap fibroatheroma (iMAP-derived TCFA); (ii) thick-cap fibroatheroma; (iii) pathological intimal thickening; (iv) fibrotic plaque; and (v) fibrocalcific plaque. ResultsCulprit lesions had smaller minimum lumen cross-sectional area (MLA) with greater plaque burden compared to non-culprit lesions. Volumetric analysis showed that culprit lesions had longer length and larger vessel and plaque volumes compared to non-culprit lesions. iMAP-IVUS revealed that culprit lesions presented more NC and fibrofatty volume, both at lesion level and at the MLA site (all P<0.001). Any fibroatheroma was more frequently identified in culprit lesions compared with non-culprit lesions (93% vs. 78.9%, P=0.001), anywhere within the lesion 19.0%, P<0.001) as well as at the MLA site (18.0% vs. 9.5%, P=0.07). ConclusionsThree-vessel radiofrequency iMAP-IVUS demonstrated a greater plaque burden and higher prevalence of any fibroatheroma as well as iMAP-derived TCFAs in culprit versus non-culprit lesions in patients presenting with STEMI or non-STEMI undergoing percutaneous coronary intervention. (c) 2017 Wiley Periodicals, Inc.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Intervent Cardiol, Sao Paulo, Brazil
dc.description.affiliationCardiovasc Res Fdn, IVUS Core Lab, New York, NY USA
dc.description.affiliationColumbia Univ, Med Ctr, Dept Intervent Cardiol, New York, NY USA
dc.description.affiliationHosp Israelita Albert Einstein, Dept Intervent Cardiol, Ave Albert Einstein 627 Morumbi, BR-05652000 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Intervent Cardiol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipBoston Scientific
dc.description.sponsorshipSt. Jude Medical
dc.description.sponsorshipVolcano Corporation
dc.description.sponsorshipInfraReDx
dc.format.extent1107-1114
dc.identifierhttp://dx.doi.org/10.1002/ccd.26954
dc.identifier.citationCatheterization And Cardiovascular Interventions. Hoboken, v. 90, n. 7, p. 1107-1114, 2017.
dc.identifier.doi10.1002/ccd.26954
dc.identifier.issn1522-1946
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58098
dc.identifier.wosWOS:000417651000010
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofCatheterization And Cardiovascular Interventions
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectintravascular ultrasounden
dc.subjectacute myocardial infarctionen
dc.subjectatherosclerosisen
dc.titleTissue characterization and phenotype classification in patients presenting with acute myocardial infarction: Insights from the iWonder studyen
dc.typeinfo:eu-repo/semantics/article
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