Body composition and lipodystrophy in prepubertal HIV-infected children

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dc.contributor.authorPalchetti, Cecília Zanin [UNIFESP]
dc.contributor.authorPatin, Rose Vega [UNIFESP]
dc.contributor.authorGouvêa, Aida de Fátima Thomé Barbosa [UNIFESP]
dc.contributor.authorSzejnfeld, Vera Lucia [UNIFESP]
dc.contributor.authorSucci, Regina Célia de Menezes [UNIFESP]
dc.contributor.authorOliveira, Fernanda Luisa Ceragioli [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:45:17Z
dc.date.available2015-06-14T13:45:17Z
dc.date.issued2013-02-01
dc.description.abstractOBJECTIVE: To identify lipodystrophy in prepubertal HIV-infected children using anthropometric parameters and body composition assessment. METHODS: Cross-sectional study including 40 prepubertal HIV-infected children of both genders seen at the Care Center of the Division of Pediatric Infectious Diseases - Universidade Federal de São Paulo (UNIFESP), São Paulo city, Brazil, was carried out from August to December 2008. Age, clinical and immunological status, prophylaxis, transmission and highly active antiretroviral therapy were recorded. Body mass index z-score and height-for-age z-score were calculated to characterize the nutritional status. Circumferences were measured with flexible tape and skinfolds were assessed by an adipometry. Fat mass and lean mass were determined by dual-energy X-ray absorptiometry. Presence of clinical signs of lipodystrophy was assessed by a trained clinician. Data were analyzed using SPSS 12.0 software. RESULTS: The mean age and standard deviation were 9.8 (1.2) years, 50% were girls and 82.5% children from B and C categories. Clinical lipodystrophy and dislypidemia were present in 27.5% and 70%, respectively. The trunk to arm ratio and the limb to trunk ratio had positive association with lipodystrophy. Patients with lipodystrophy had short stature, higher triglycerides values and lower HDL-cholesterol. CONCLUSION: The ratios obtained by skinfolds and dual-energy X-ray absorptiometry measurements can be considered as indicators of preclinical lipodystrophy. The cutoff points have not been determined yet; however, continuous assessment may be useful to identify early body composition changes.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina
dc.description.affiliationUnifespUNIFESP, EPM
dc.description.sourceSciELO
dc.format.extent01-06
dc.identifierhttp://dx.doi.org/10.1016/j.bjid.2012.12.001
dc.identifier.citationBrazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 17, n. 1, p. 01-06, 2013.
dc.identifier.doi10.1016/j.bjid.2012.12.001
dc.identifier.fileS1413-86702013000100001.pdf
dc.identifier.issn1413-8670
dc.identifier.scieloS1413-86702013000100001
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/7617
dc.identifier.wosWOS:000315068200001
dc.language.isoeng
dc.publisherBrazilian Society of Infectious Diseases
dc.relation.ispartofBrazilian Journal of Infectious Diseases
dc.rightsAcesso aberto
dc.subjectHIVen
dc.subjectChilden
dc.subjectLipodystrophyen
dc.subjectBody compositionen
dc.subjectAnthropometryen
dc.titleBody composition and lipodystrophy in prepubertal HIV-infected childrenen
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