beta-Hydroxy-beta-methylbutyrate (HM beta) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathway

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dc.contributor.authorPimentel, Gustavo Duarte [UNIFESP]
dc.contributor.authorRosa Neto, José Cesar [UNIFESP]
dc.contributor.authorLira, Fabio Santos da [UNIFESP]
dc.contributor.authorZanchi, Nelo Eidy
dc.contributor.authorRopelle, Eduardo Rochete
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorSantos, Ronaldo Vagner Thomatieli dos [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:06:12Z
dc.date.available2016-01-24T14:06:12Z
dc.date.issued2011-02-23
dc.description.abstractbeta-Hydroxy-beta-methylbutyrate (HM beta) supplementation is used to treat cancer, sepsis and exercise-induced muscle damage. However, its effects on animal and human health and the consequences of this treatment in other tissues (e. g., fat and liver) have not been examined. the purpose of this study was to evaluate the effects of HM beta supplementation on skeletal muscle hypertrophy and the expression of proteins involved in insulin signalling. Rats were treated with HM beta (320 mg/kg body weight) or saline for one month. the skeletal muscle hypertrophy and insulin signalling were evaluated by western blotting, and hormonal concentrations were evaluated using ELISAs. HM beta supplementation induced muscle hypertrophy in the extensor digitorum longus (EDL) and soleus muscles and increased serum insulin levels, the expression of the mammalian target of rapamycin (mTOR) and phosphorylation of p70S6K in the EDL muscle. Expression of the insulin receptor was increased only in liver. Thus, our results suggest that HM beta supplementation can be used to increase muscle mass without adverse health effects.en
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Physiol Nutr, São Paulo, Brazil
dc.description.affiliationState Univ Campinas UNICAMP, Dept Internal Med, FCM, Campinas, SP, Brazil
dc.description.affiliationUniv São Paulo, Dept Cell Biol & Dev, Mol Cell Biol Study Grp, Inst Biomed Sci 1, São Paulo, Brazil
dc.description.affiliationState Univ Campinas UNICAMP, Fac Appl Sci, Limeira, SP, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Biosci, São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Physiol Nutr, São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Biosci, São Paulo, Brazil
dc.description.provenanceMade available in DSpace on 2016-01-24T14:06:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-02-23. Added 1 bitstream(s) on 2016-01-31T13:34:52Z : No. of bitstreams: 1 WOS000288172100001.pdf: 873629 bytes, checksum: c2a7065868869545dd7db1c1995c18dc (MD5)en
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2008/03533-1
dc.format.extent7
dc.identifierhttps://dx.doi.org/10.1186/1743-7075-8-11
dc.identifier.citationNutrition & Metabolism. London: Biomed Central Ltd, v. 8, 7 p., 2011.
dc.identifier.doi10.1186/1743-7075-8-11
dc.identifier.fileWOS000288172100001.pdf
dc.identifier.issn1743-7075
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/33472
dc.identifier.wosWOS:000288172100001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofNutrition & Metabolism
dc.rightsAcesso aberto
dc.titlebeta-Hydroxy-beta-methylbutyrate (HM beta) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathwayen
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