Exercise training-induced enhancement in myocardial mechanics is lost after 2 weeks of detraining in rats

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dc.contributor.authorBocalini, Danilo Sales [UNIFESP]
dc.contributor.authorCarvalho, Eduardo V. A. [UNIFESP]
dc.contributor.authorMello de Sousa, Ana Flavia [UNIFESP]
dc.contributor.authorLevy, Rozeli Ferreira [UNIFESP]
dc.contributor.authorTucci, Paulo J. F. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Paraiba
dc.date.accessioned2016-01-24T14:05:06Z
dc.date.available2016-01-24T14:05:06Z
dc.date.issued2010-07-01
dc.description.abstractExercise training is assumed to improve myocardial function; however, the role of detraining and its effect on myocardial parameters are still unclear. the aim of the present study was to evaluate the effect of detraining on ventricular remodeling and myocardial mechanical parameters after an 8 week (5 days/week, 60 min/day) swimming training period. Forty-three female Wistar rats were distributed into six groups: trained (T, n = 9), detrained 2 weeks (D2, n = 8), detrained 4 weeks (D4, n = 8) and their respective controls: untrained (U, n = 5), untrained 2 weeks (U2, n = 5) and untrained 4 weeks (U4, n = 5). Detrained rats underwent training and then remained sedentary (i.e., detraining) for 2 or 4 weeks. After training, the T group demonstrated increased physical capacity, left ventricular (LV) posterior wall thickness, and LV end-diastolic diameter, along with decreased heart rate, as evaluated by echocardiogram. in addition, the inotropism and lusitropism parameters studied on papillary muscles showed improvement in the T group (P < 0.05). However, after just 2 weeks of detraining, all parameters regressed back to values which were similar to those of the untrained groups. in conclusion, our results confirmed that exercise training is capable of inducing myocardial remodeling and improving contractile performance; however, these changes are completely lost after a short period of detraining.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, BR-04022000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, BR-04022000 São Paulo, Brazil
dc.description.affiliationUniv Fed Paraiba, Dept Physiotherapy, BR-58059900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, BR-04022000 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, BR-04022000 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent909-914
dc.identifierhttp://dx.doi.org/10.1007/s00421-010-1406-x
dc.identifier.citationEuropean Journal of Applied Physiology. New York: Springer, v. 109, n. 5, p. 909-914, 2010.
dc.identifier.doi10.1007/s00421-010-1406-x
dc.identifier.issn1439-6319
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32666
dc.identifier.wosWOS:000279195200013
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofEuropean Journal of Applied Physiology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectSwimming trainingen
dc.subjectMyocardial contractilityen
dc.subjectCardiac remodelingen
dc.subjectDetrainingen
dc.titleExercise training-induced enhancement in myocardial mechanics is lost after 2 weeks of detraining in ratsen
dc.typeinfo:eu-repo/semantics/article
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