Incidence and Risk Factors for Cardiovascular Collapse After Unplanned Extubations in the Pediatric ICU

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dc.citation.issue7]
dc.citation.volume62]
dc.contributor.authorLucas da Silva, Paulo Sergio
dc.contributor.authorMachado Fonseca, Marcelo Cunio [UNIFESP]
dc.coverageIrving
dc.date.accessioned2020-06-26T16:30:32Z
dc.date.available2020-06-26T16:30:32Z
dc.date.issued2017
dc.description.abstractBACKGROUND: Cardiovascular collapse is a life-threatening event after unplanned extubations (UEs) in the pediatric ICU (PICU). However, there is a paucity of pediatric studies assessing this complication. We sought to assess the incidence, risk factors, and outcome of cardiovascular collapse after UEs in PICU patients. METHODS: All children who had been mechanically ventilated for >= 12 h were prospectively tracked for UEs over an 8-y period. Subjects were included in the study if they were between ages 1 month and 16 y and had experienced UE. They were analyzed in 2 groups: those with cardiovascular collapse (defined as the need for cardiopulmonary resuscitation or circulatory dysfunction immediately after UE) and those with no cardiovascular collapse. RESULTS: Of the 847 subjects, 109 UEs occurred in 14,293 intubation days (0.76 UEs/100 intubation days), with 21 subjects (19.2%) experiencing cardiovascular collapse, of which 10 required cardiopulmonary resuscitation. Compared with subjects without cardiovascular collapse after UE, children with cardiovascular collapse were younger(<6 months old), with respiratory failure from lower respiratory tract diseases, lower P-aO2/F-IO2 (218 vs 282 mm Hg), and higher oxygenation indices (5.5 vs 3.5) before UE events. Logistic regression revealed that only an age <6 months old was strongly associated with cardiovascular collapse (odds ratio 3.4, P = .03). There were no differences between cardiovascular collapse and non-cardiovascular collapse subjects regarding the length of hospital stay, ventilator-associated pneumonia rate, and mortality. CONCLUSIONS: Cardiovascular collapse is a frequent complication of UEs, particularly in the youngest children. Specific bundles to prevent UEs may reduce morbidity related to these events.en
dc.description.affiliationHosp Servidor Publ Municipal, Dept Pediat, Pediat Intens Care Unit, Rua Castro Alves 60, BR-01532900 Sao Paulo, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Hlth Technol Assessment Unit, Sao Paulo, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Hlth Technol Assessment Unit, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent896-903
dc.identifierhttp://dx.doi.org/10.4187/respcare.05346]
dc.identifier.citationRespiratory Care. Irving, v. 62, n. 7, p. 896-903, 2017.
dc.identifier.doi10.4187/respcare.05346
dc.identifier.fileWOS000404102600006.pdf
dc.identifier.issn0020-1324
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53607
dc.identifier.wosWOS:000404102600006
dc.language.isoeng
dc.publisherDaedalus Enterprises Inc
dc.relation.ispartofRespiratory Care
dc.rightsACESSO ABERTO
dc.subjectcomplicationsen
dc.subjectendotracheal extubationen
dc.subjectoutcomesen
dc.subjectpediatric intensive care uniten
dc.subjectunplanned extubationen
dc.titleIncidence and Risk Factors for Cardiovascular Collapse After Unplanned Extubations in the Pediatric ICUen
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