Obstructive sleep apnea and objective short sleep duration are independently associated with the risk of serum vitamin D deficiency

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dc.citation.issue7]
dc.citation.volume12]
dc.contributor.authorPiovezan, Ronaldo D. [UNIFESP]
dc.contributor.authorHirotsu, Camila [UNIFESP]
dc.contributor.authorFeres, Marcia C. [UNIFESP]
dc.contributor.authorCintra, Fatima D. [UNIFESP]
dc.contributor.authorAndersen, Monica L. [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorPoyares, Dalva [UNIFESP]
dc.coverageSan Francisco
dc.date.accessioned2020-06-26T16:30:16Z
dc.date.available2020-06-26T16:30:16Z
dc.date.issued2017
dc.description.abstractBackground Studies demonstrate an association between vitamin D (25(OH) D) deficiency and sleep disturbances, such as obstructive sleep apnea (OSA) and short sleep duration. However, to date, no studies have concurrently and objectively evaluated the effect of these factors on 25(OH) D. Objectives To evaluate whether OSA and objective short sleep duration are independently associated with reduced 25(OH) D in an adult population sample. Methods A cross-sectional study included 657 individuals from the city of Sao Paulo, Brazil, as part of the ERA project. Participants fulfilled questionnaires and underwent clinical evaluation, polysomnography and blood sample collection for 25(OH) D quantification. OSA was classified into three categories (mild, moderate and severe). The risk of 25(OH) D deficiency was considered as levels<30 ng/mL. Short sleep duration was defined as total sleep time<6 hours. Results The risk of 25(OH) D deficiency was observed in 59.5% of the sample, affecting more individuals of the female gender, obese, with African American ethnicity, and those that were smokers, sedentary and presented hypertension and diabetes. In the final logistic model adjusted for age, gender, ethnicity, obesity, smoking, hypertension, diabetes, sedentary lifestyle, seasonality and creatinine serum levels, both OSA and short sleep duration showed significant independent associations with the risk of 25(OH) D deficiency (moderate OSA: OR for 25(OH) D<30 = 2.21, 95% CI: 1.35-3.64, p<0.01en
dc.description.abstractsevere OSA: OR for 25(OH) D<30 = 1.78, 95% CI: 1.06-3.00, p = 0.03en
dc.description.abstractshort sleep duration: OR for 25(OH) D<30 = 1.61, 95% CI: 1.15-2.26, p = 0.01). After a subgroup analysis, similar results were observed only in participants >= 50 years. Conclusion OSA and short sleep duration are independently associated with the risk of 25(OH) D deficiency in an adult population. Age-related changes in vitamin D metabolism and the frequency of sleep disorders may be involved in these associations. Future studies exploring whether 25(OH) D levels may modulate OSA and sleep curtailment-related outcomes are needed.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Med, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Med, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo
dc.description.sponsorshipIDFAPESP: 2014/15259-2
dc.description.sponsorshipIDFAPESP: 98/14303-3
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0180901]
dc.identifier.citationPlos One. San Francisco, v. 12, n. 7, p. -, 2017.
dc.identifier.doi10.1371/journal.pone.0180901
dc.identifier.fileWOS000405464100120.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53457
dc.identifier.wosWOS:000405464100120
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleObstructive sleep apnea and objective short sleep duration are independently associated with the risk of serum vitamin D deficiencyen
dc.typeinfo:eu-repo/semantics/article
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