Biperiden (an M1 antagonist) reduces memory consolidation of cocaine-conditioned place preference

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dc.contributor.authorZacarias, Marina S. [UNIFESP]
dc.contributor.authorRamos, Anna C. [UNIFESP]
dc.contributor.authorAlves, Danielle R. [UNIFESP]
dc.contributor.authorGalduroz, Jose C. F. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:27:06Z
dc.date.available2016-01-24T14:27:06Z
dc.date.issued2012-04-04
dc.description.abstractIt is well-known that cocaine dependence is a public health issue, and several studies stress the need to look for new and more effective treatments. Although the mesolimbic dopamine (DA) system, which originates in the ventral tegmental area (VTA) and projects to several forebrain structures, is known to be critically involved in the neurobiology of cocaine dependence, acetylcholine (ACh) has also been shown to play an important role in cocaine dependence via its action on this reward system. ACh is also important in the formation of hippocampal memory associated with appetitive behavior. Thus, the aim of this study was to evaluate the effect of biperiden, an ACh antagonist with high affinity for muscarinic M1 type receptors, on the acquisition of cocaine-conditioned place preference (CPP) in mice. the cocaine and biperiden were dissolved in sterile saline and were administered intraperitoneally at a dose of 10 mg/kg. the conditioning regime was 8 days long, and the cholinergic antagonist was given immediately at the end of each conditioning session. the test for CPP occurred 24 h after the last session. the results showed that animals treated with biperiden spent significantly less time in the cocaine-paired compartment than did the ones treated with saline. This finding represents a reduction in the consolidation of cocaine-induced CPP. One hypothesis that could explain this outcome focuses on the action of cholinergic antagonists on the consolidation of contextual memories. the amnesic effect of M1 antagonists on aversive tasks and on morphine CPP has been demonstrated when administered before the training or the conditioning session. the present study highlights the possibility of impairment in the acquisition of an appetitive memory, even when the cholinergic drug is administered after the conditioning session. This protocol also rejects the possibility of performance disturbance and suggests a possible pharmacological tool in the treatment of cocaine dependence. (c) 2012 Published by Elsevier Ireland Ltd.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent129-131
dc.identifierhttp://dx.doi.org/10.1016/j.neulet.2012.01.073
dc.identifier.citationNeuroscience Letters. Clare: Elsevier B.V., v. 513, n. 2, p. 129-131, 2012.
dc.identifier.doi10.1016/j.neulet.2012.01.073
dc.identifier.issn0304-3940
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34791
dc.identifier.wosWOS:000303090300005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience Letters
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectAcetylcholineen
dc.subjectBiperidenen
dc.subjectCocaineen
dc.subjectMemory consolidationen
dc.subjectConditioned place preferenceen
dc.titleBiperiden (an M1 antagonist) reduces memory consolidation of cocaine-conditioned place preferenceen
dc.typeinfo:eu-repo/semantics/article
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